Non-invasive tissue thermometry system and method

• US 4,807,633 A
• Filed: 05/21/1986
• Issued: 02/28/1989
• Est. Priority Date: 05/21/1986
• Status: Expired due to Term

• Current Assignee: Indianapolis Center for Advanced Research, Inc.
• Original Assignee: Indianapolis Center for Advanced Research, Inc.
• Inventors: Fry, Francis J.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/865,399
• Time in Patent Office: 1,014 Days
• Field of Search: 128/660, 128/24 A, 128/804, 128/736, 73/597, 73/599, 73/602, 374/117, 374/119, 374/159
• US Class Current: 600/438
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 8/5223 for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012
• CPC Class Codes: G01K 11/22 using measurement of acoustic effects
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

It has been observed that attenuation of a transmitted or reflected beam of ultrasound in tissue irradiated with such a beam having a power intensity in the tissue in the non-linear range will change measurably as the tissue temperature changes. Based upon this observation, a method and apparatus for non-invasive thermometry include periodically interrogating the tissue with an ultrasonic beam having a power intensity sufficient such that the power intensity of the beam in the tissue is in the non-linear range. Attenuation coefficients based upon the attenuation of the power intensity of the ultrasonic beam due to the tissue are then periodically determined. Temperature changes in the tissue are determined based upon differences between the determined attenuation coefficients.

Claims

1. In a method of non-invasively determining a temperature change in tissue, comprising the steps of irradiating the tissue with an ultrasonic beam, receiving the irradiating ultrasonic beam a first time after it has passed through the tissue and been attenuated thereby, determining the attenuation of the power intensity of the irradiating beam due to its passage through the tissue, irradiating the tissue a second time with an ultrasonic beam, receiving the irradiating ultrasonic beam a second time after it has passed through the tissue and been attenuated thereby, determining for a second time the attenuation of the power intensity of the irradiating beam due to its passage through the tissue, comparing the attenuations of the intensity of the ultrasonic beam received the first and second times due to the tissue, and determining the temperature change of the tissue based upon the comparison, the improvement wherein the irradiating ultrasonic beam is in the non-linear power range in the tissue both the first and second times.

2. The method of claim 1 wherein the irradiating ultrasonic beam power in the tissue is at least 100 watts/cm² both the first and second times.

3. The method of claim 1 wherein the step of determining the attenuation of the power intensity of the irradiating beam due to its passage through the tissue comprises the steps of measuring the power intensity of the irradiating power beam at its origin, measuring the power intensity of the irradiating beam as it is received, and comparing the power intensity of the irradiating beam at its origin to the power intensity of the irradiating beam as it is received.

4. The method of claim 1 wherein the step of determining the temperature change of the tissue based upon the comparison comprises the step of predetermining a range of attenuations for a range of temperatures for a type of tissue similar to the tissue.

5. In an apparatus for non-invasively determining a temperature change in tissue, the apparatus comprising means for irradiating the tissue a first time and a second time with an ultrasonic beam, means for receiving the irradiating ultrasonic beam a first time and a second time after it has passed through the tissue and been attenuated thereby, means for determining a first time and a second time the attenuation of the power intensity of the irradiating beam due to its passage through the tissue, means for comparing the attenuations of the intensity of the ultrasonic beam received the first and second times due to the tissue, and means for determining the temperature change of the tissue based upon the comparison, the improvement wherein the means for irradiating the tissue a first time and second time with an ultrasonic beam comprises means for irradiating the tissue a first time and a second time with an ultrasonic beam whose power intensity is in the non-linear power range in the tissue both the first and second times.

6. The apparatus of claim 5 wherein the means for irradiating the tissue a first time and a second time with an ultrasonic beam whose power intensity is in the non-linear power range in the tissue comprises means for irradiating the tissue a first time and a second time with an ultrasonic beam whose power intensity is at least 100 watts/cm² in the tissue.

7. The apparatus of claim 5 wherein the means for determining the attenuation of the power intensity of the irradiating beam due to its passage through the tissue comprises means for measuring the power intensity of the irradiating beam at its origin and for measuring the power intensity of the irradiating beam as it is received, and means for comparing the power intensity of the irradiating beam at its origin to the power intensity of the irradiating beam as it is received.

8. The apparatus of claim 5 wherein the means for determining the temperature change of the tissue based upon the comparison comprises means for storing a predetermined range of attenuations and a corresponding predetermined range of temperatures for a type of tissue similar to the tissue.