Disposable cell culture chamber with remote access

• US 4,810,246 A
• Filed: 11/04/1987
• Issued: 03/07/1989
• Est. Priority Date: 11/04/1987
• Status: Expired due to Term

• Current Assignee: Dow Corning Wright Corporation Arlington TN, L3 Technologies, Inc. (L3Harris Technologies, Inc.)
• Original Assignee: L3 Technologies, Inc. (L3Harris Technologies, Inc.)
• Inventors: Kantrowitz, Adrian, Freed, Paul S., Frisch, Eldon E.
• Primary Examiner(s): Pellegrino, Stephen C.
• Application Number:
  US07/116,311
• Time in Patent Office: 489 Days
• Field of Search: 604/175, 604/174, 604/264, 604/905, 604/93, 604/8-10
• US Class Current: 604/175
• CPC Class Codes: A61M 2039/0261 Means for anchoring port to the body, or ports having a special shape or being made of a specific material to allow easy implantation/integration in the body
• CPC Class Codes: A61M 2039/0291 method or device for implanting it in the body
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053

Abstract

A combination is provided of a percutaneous lead designed for implantation in the human body, which lead has a surface which is adapted to pass through and be exposed to the dermis of a patient when the device is implanted. Said surface is adapted to receive the growth of a cultured autogenous fibroblast coating on an etched, nanoporous surface. A liquid tight sealed removable, disposable chamber encloses said surface, said chamber being provided with openings for introduction therein of finely divided living dermal tissue suspended in a liquid carrier, thus providing a means for formation of the cultured surfaces which can be easily handled. The disposable chamber is removed and discarded at the time of surgery.

Claims

1. In combination:

A. a percutaneous access device designed for implantation in the human body, said device having a component adapted to extend through the skin to provide access from outside of the body to a subcutaneous location within the body and having a peridermal component with a surface which is adapted to be implanted immediately beneath the dermis of a patient, said surface having a porous texture and thus being adapted to receive the growth thereon of a cultured autogenous fibroblast coating thereon, and

B. a liquid tight sealed removable, disposable chamber enclosing said surface, said chamber being provided with a remotely accessible opening for introduction therein of finely divided living dermal tissue suspended in a liquid carrier.

2. A device according to claim 1 wherein said chamber is formed of a silicone elastomer.

3. A device according to claim 1 wherein a tube is provided through said opening for addition of said dermal tissue and a second tube is provided to permit venting of said chamber.

4. A device according to claim 1 wherein said surface is nanoporous.

5. A device according to claim 1 wherein said component is a conduit attached to the top thereof adapted to extend exteriorly of the body of the patient and a conduit tube in fluid communication therewith extending from the bottom thereof which is adapted to be surgically implanted within the patients body.

6. A device according to claim 5 wherein a sterile plastic container surrounds said chamber and said catheters, said container being hermetically enclosed with the exception of an opening through which a tube connected to the opening in the chamber extends for addition of a dermal tissue suspension.