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Volume independent diagnostic device

  • US 4,810,470 A
  • Filed: 06/19/1987
  • Issued: 03/07/1989
  • Est. Priority Date: 06/19/1987
  • Status: Expired due to Fees
First Claim
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1. A device for metering a constant volume of a liquid to an analyte assay area and for determining analyte concentrations in liquid samples consisting essentially of a first bibulous matrix devoid of reagent;

  • a second bibulous matrix containing a suitable test reagent in a sufficient quantity for interaction with a particular analyte constituent of the liquid to produce a detectable change in the second bibulous matrix upon contact with the liquid, said second bibulous matrix being disposed sufficiently close to the first bibulous matrix and so positioned and sized that the interaction between the analyte constituent of the liquid and the testing reagent is quantitatively detected; and

    a liquid impermeable barrier disposed over a portion but not all of the first bibulous matrix and at least a portion of the second bibulous matrix such that liquid applied to the first bibulous matrix at an area spaced from the second bibulous matrix will be metered into the second bibulous matrix only to the point of liquid saturation of the second bibulous matrix such that the quantitative determination of the analyte constituent of the liquid is independent of the volume of liquid sample applied to the first bibulous matrix.

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