Method and apparatus for examining the interior of semi-opaque objects

• US 4,810,875 A
• Filed: 02/02/1987
• Issued: 03/07/1989
• Est. Priority Date: 02/02/1987
• Status: Expired due to Term

• Current Assignee: Wyatt Technology Corporation
• Original Assignee: Wyatt Technology Corporation
• Inventors: Wyatt, Philip J.
• Primary Examiner(s): Westin, Edward P.
• Application Number:
  US07/009,447
• Time in Patent Office: 764 Days
• Field of Search: 250/227, 250/213 VT, 250/578, 128/303.1, 128/362, 128/633, 128/664, 128/665, 378/37, 350/96.1, 350/96.26, 356/448
• US Class Current: 250/227.11
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

A highly collimated light beam, such as produced by a laser, is coupled by optical means directly onto a semi-opaque object such as a human breast. The light transmitted and scattered therein is collected at a fixed surface element and direction relative to the incident light, and coupled optically into an image intensifier, preserving the spatial intensity variations passing through said fixed surface element. The intensified image is then collected on an array of detector elements which digitizes and then transfers said preserved image into memory means where it is processed to characterize the interior of said object. This invention has particular application to the early detection of breast cancer.

Claims

1. A method for the examination of the interior of a semi-opaque object by collimated light means comprised of the following steps:

A. forming a narrow, collimated beam of light;

B. passing such beam into an optical transmission means;

C. coupling said optical transmission means onto said semi-opaque object at a specified entrance surface region using a refractive index matching means, suitably selected to minimize the refractive index discontinuity between that of said optical transmission means and that of said semi-opaque object;

D. coupling that fraction of said light which has scattered within and impinged upon a specified surface exit region of said object, by similar refractive index matching means to an optical collection means at said specified surface region;

E. coupling said optical collection means into a light amplification means which preserves the spatial intensity variations incident thereon and collected at said specified surface region by said optical collection means;

F. impinging said amplified light on an array of photodetectors;

G. converting each detected intensity corresponding to each photodetector element of said array into a numerical value and then transmitting each such value into a memory storage means;

H. processing and analyzing said numerical values in said memory means by computer means; and

characterizing thereby the region of said examined object causing the spatial variation of said intensity values;

I. repeating said measurement at different orientations of said incident coupled optical transmission means and said coupled optical collection means with respect to said specified surface regions;

J. varying said entrance and exit surface regions and repeating steps G, H and I;

K. characterizing thereby the inhomogeneities within said semi-opaque object causing the spatial variations of the said detected intensity values.

2. The method of claim 1 where said collimated beam of light is essentially monochromatic.

3. The method of claim 1 wherein the narrow, collimated beam of light is from a laser.

4. The method of claim 3 where the laser light is linearly polarized.

5. The method of claim 3 where the laser light is unpolarized.

6. The method of claim 3 where said optical transmission means includes a first lens element focusing said laser beam onto a multimode optical fiber, and other end of said fiber is terminated at the focal point of a second lens element.

7. The method of claim 1 where the light amplification means is a microchannel plate.

8. The method of claim 7 where the microchannel plate is a chevron plate.

9. The method of claim 7 where the microchannel plate is a C-plate.

10. The method of claim 7 where the microchannel plate is a Z-plate.

11. The method of claim 1 where the array of photodetectors is comprised of photodiodes.

12. The method of claim 1 where the array of photodetectors forms a charge coupled device.

13. The method of claim 3 where the laser is a He-Ne laser.

14. The method of claim 3 where the laser produces red light.

15. The method of claim 3 where the laser produces infrared light.

16. The method of claim 1 where the semi-opaque object is a human breast.

17. The method of claim 1 where the conversion of said detected intensities is achieved by an analog-to-digital converter.

18. The method of claim 1 wherein said amplified light is made to impinge upon a lens element before impinging on said array of photodetectors forming, thereby, an image of a region interior to said object on said photodetector array.

19. The method of claim 1 where the processing of said numerical values in said memory includes the processes of signal recovery.

20. The method of claim 6 where each said lens element is a half pitch gradient refractive index lens.

21. The method of claim 1 where said refractive index matching means is a fluid.

43. The method of claim 1 where measurement is made of the relative orientations and positions of the transmission and collection means coupled to the semi-opaque object being examined.

44. The method of claim 43 where said measured relative orientations and positions of said optical transmission and collection means coupled to said semi-opaque object being examined are recorded.

45. The method of claim 44 where the measurements derived therein are used to calculate the path through the semi-opaque object.

46. The method of claim 44 where the measurements derived therein are used to calculate the locations of the scattering objects therewithin and the angle of scattering therefrom with respect to the direction of the incident light.

47. The method of claim 3 where said processing and analysing of said collected numerical values include determination of the degree of coherence in said collected values.

22. An instrument for the examination of the interior of a semi-opaque object by collimated light means comprised of:

A. Collimated light means producing a narrow beam of light;

B. Collimated light beam optical transmission means

C. Coupled onto said semi-opaque object by refractive index matching means suitably selected to minimize the refractive index discontinuity between that of said optical transmission means and that of said semi-opaque object at a specified entrance surface;

D. Optical collection means;

said optical collection means being coupled by similar refractive index matching means to a specified exit surface region of said object through which light scattered within said object has scattered thereto;

E. Light amplification means whereby light collected from said object in step D is amplified in intensity while maintaining its spatial variations at said optical collection means;

F. Optical lens means by which said amplified light spatial variation is imaged on

G. Photodetector array means transmitting output signals proportional to incident intensities to

H. Analog-to-digital conversion means whereby each signal at each photo-detector element in converted into a digital representation stored in

I. Memory means of a

J. Computer processing means.

23. The instrument of claim 22 where said collimated beam of light is essentially monochromatic.

24. The instrument of claim 22 wherein the narrow, collimated beam of light is from a laser.

25. The instrument of claim 24 where the laser light is linearly polarized.

26. The instrument of claim 24 where the laser light is unpolarized.

27. The instrument of claim 24 where said optical transmission means includes a first lens means focusing said laser beam onto a multimode optical fiber, and other end of said fiber is terminated at the focal point of a second lens means.

28. The instrument of claim 22 where the light amplification means is a microchannel plate.

29. The instrument of claim 28 where the microchannel plate is a chevron plate.

30. The instrument of claim 28 where the microchannel plate is a C-plate.

31. The instrument of claim 28 where the microchannel plate is a Z-plate.

32. The instrument of claim 22 where the array of photodetectors is comprised of photodiodes.

33. The instrument of claim 22 where the array of photodetectors forms a charge coupled device.

34. The instrument of claim 24 where the laser is a He-Ne laser.

35. The instrument of claim 24 where the laser produces red light.

36. The instrument of claim 24 where the laser produces infrared light.

37. The instrument of claim 22 where the semi-opaque object is a human breast.

38. The instrument of claim 22 where the conversion of said detected intensities is achieved by an analog-to-digital converter.

39. The instrument of claim 22 where said amplified light is made to impinge upon a lens element before impinging on said array of photodetectors forming, thereby, an image of a region interior to said object on said photodetector array.

40. The instrument of claim 22 where said computer processing means includes the processes of signal recovery.

41. The instrument of claim 27 where each said lens means is a half pitch gradient refractive index lens.

42. The instrument of claim 22 where said refractive index matching means is a fluid.