Crosslinking of hair thiols using glutathione disulfide

• US 4,812,307 A
• Filed: 07/16/1987
• Issued: 03/14/1989
• Est. Priority Date: 07/06/1983
• Status: Expired due to Fees

• Current Assignee: Chesebrough-Pond's USA Company (Unilever PLC)
• Original Assignee: Chesebrough-Pond's USA Company (Unilever PLC)
• Inventors: Siuta-Mangano, Patricia
• Primary Examiner(s): Robinson, Ellis P.
• Assistant Examiner(s): Ruckes, Susan S.
• Application Number:
  US07/074,207
• Time in Patent Office: 607 Days
• Field of Search: 424/71, 424/72, 514/706, 568/61, 568/63, 568/66, 568/69, 132/7, 132/203, 132/204, 8/127.5, 8/127.51, 8/127.6, 8/128.1, 8/128.3
• US Class Current: 424/70.5
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 5/04 Preparations for permanent waving or straightening the hair

Abstract

Keratinous material, such as human hair, in which disulfide linkages have been reptured to form sulfhydryl groups can be set using glutathione disulfide.

Claims

1. A process for treating keratinous material in which disulfide linkages have been ruptured to form sulfhydryl groups by the action of a reducing agent which comprises contacting said keratinous material with an amount of glutathione disulfide effective to crosslink an amount of sulfhydryl groups sufficient to set the keratinous material.

2. The process as claimed in claim 1 wherein the keratinous material is human hair.

3. The process as recited in claim 1 wherein the glutathione disulfide is used in an amount ranging from about 0.1% to about 10% weight per volume.

4. A process which comprises treating hair with a reducing agent until a substantial portion of disulfide groups of the hair are converted to sulfhydryl groups and, while maintaining the hair in a fixed position, subjecting the hair to treatment with glutathione disulfide in an amount and under conditions sufficient to set the hair.

5. A process which comprises treating human hair, while the hair is mechanically maintained in a suitable condition of curl with a mixture of a reducing agent capable of rupturing disulfide linkages in the hair and an amount of glutathione disulfide effective to crosslink an amount of sulfhydryl groups sufficient to set the keratinous material.