Methods for enhancing differentiation and proliferation of hematopoietic progenitor cells

• US 4,812,443 A
• Filed: 06/24/1985
• Issued: 03/14/1989
• Est. Priority Date: 06/29/1984
• Status: Expired due to Fees

• Current Assignee: Kuraray Company Limited
• Original Assignee: Kuraray Company Limited
• Inventors: Shimamura, Michiya, Takak, Fumimaro, Mizuno, Masao, Urabe, Akio
• Primary Examiner(s): FRIEDMAN, STANLEY
• Application Number:
  US06/748,403
• Time in Patent Office: 1,359 Days
• Field of Search: 514/143
• US Class Current: 514/143
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: C07C 33/02 Acyclic alcohols with carbon-to-carbon double bonds

Abstract

A medicament containing a compound of the formula ##STR1## wherein ##STR2## is a trans-isoprene unit, ##STR3## is a cis-isoprene unit, and n is an integer of from 12 to 18, or a pharmaceutically acceptable ester thereof.

The medicament is useful for the treatment of anemia, particularly aplastic anemia.

Claims

1. A method for enhancing differentiation and proliferation of hematopoietic progenitor cells in a mammal, which comprises administering to the mammal an effective amount of a compound of the formula ##STR11## wherein ##STR12## is a trans-isoprene unit, ##STR13## is a cis-isoprene unit, and n is an integer of from 12 to 18, or a pharmaceutically acceptable ester thereof.

2. A method for enhancing differentiation and proliferation of hematopoietic progenitor cells in a mammal, which comprises administering to the mammal an effective amount of a compound of the formula ##STR14## wherein ##STR15## is a trans-isoprene unit, ##STR16## is a cis-isoprene unit, and n is an integer of from 12 to 18, or a pharmaceutically acceptable ester thereof selected from the group consisting of a fatty acid ester, a phosphoric acid ester and a monomannosyl phosphate ester.

7. The method of claim 2 wherein the compound is administered orally or parenterally.

8. The method of claim 2 wherein the compound is administered in a dose of 0.05 to 1,000 mg/kg/day.

3. A method for enhancing differentiation and proliferation of hematopoietic progenitor cells in a mammal, which comprises administering to the mammal an effective amount of a composition containing a mixture of compounds of the formula ##STR17## wherein ##STR18## is a trans-isoprene unit, ##STR19## is a cis-isoprene unit, and n is an integer of from 12 to 18, or a pharmaceutically acceptable ester thereof selected from the group consisting of a fatty acid ester, a phosphoric acid ester and a monomannosyl phosphate ester, wherein the distribution of n in the compounds of formula (I) or the esters thereof is within the following ranges:

space="preserve" listing-type="tabular">______________________________________ weight % based on n in formula (I) weight of said mixture ______________________________________ 12 0-6 13 4-17 14 20-35 15 30-50 16 10-25 17 2-10 18 0-5. ______________________________________

4. The method of claim 3 wherein the composition is administered orally or parenterally.

5. The method of claim 3 wherein the compounds are administered in a total dose of 0.05 to 1,000 mg/kg/day.

6. The method of claim 3 wherein the distribution of n in the compounds of formula (I) or the esters thereof is within the following ranges:

space="preserve" listing-type="tabular">______________________________________ weight % based on n in formula (I) weight of said mixture ______________________________________ 12 0.1-6 13 5-14 14 23-32 15 32-47 16 11-20 17 2-6 18 0.1-2. ______________________________________