Nerve fiber stimulation using symmetrical biphasic waveform applied through plural equally active electrodes

• US 4,813,418 A
• Filed: 02/02/1987
• Issued: 03/21/1989
• Est. Priority Date: 02/02/1987
• Status: Expired due to Term

• Current Assignee: Encore Medical Asset Corporation (Enovis Corp.)
• Original Assignee: Staodynamics, Inc.
• Inventors: Harris, Frank W.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/009,760
• Time in Patent Office: 778 Days
• Field of Search: 128/419 PG, 128/421-423
• US Class Current: 607/156
• CPC Class Codes: A61N 1/36021 for treatment of pain

Abstract

Nerve fiber stimulation is disclosed using a symmetrical biphasic waveform applied through plural active electrodes to increase the activity of the nerve fibers then selected for stimulation. Bi-phased pulse pairs are repeatedly symmetrically generated and applied to the nerve fibers to be stimulated with the first pulse of each pulse pair being a positive polarity pulse applied through a first electrode to cause the nerve fibers to be set into the refractory period and with the second pulse of each pulse pair being a negative polarity pulse applied through the first electrode to occur substantially at the end of the refractory period for the nerve fibers then to be stimulated to thereby excite those nerve fibers. The pulse pairs are also applied in inverted polarity through a second electrode with the inverted second pulse thus resulting in an applied positive pulse at the second electrode to cause the nerve fibers to be stimulated to be set into the refractory period and with the inverted first pulse of the succeeding pulse pair resulting in an applied negative pulse at the second electrode occurring substantially at the end of the refractory period for the particular nerve fibers to be stimulated to thereby excite those nerve fibers. Plural channels having dual active electrodes can be provided with applied bi-phased pulses being timewise offset from one another to maintain isolation between channels.

Claims

1. A device for providing electrical stimulation through plural active electrodes to preselected nerve fibers having known refractory periods and enhanced excitability conditions that occur during known periods following the occurrence of an action potential, said device comprising:

generating means for generating a series of output pulse pairs with each said pair having first and second pulses of positive and negative polarity, respectively, and with said first pulse occurring timewise before said second pulse, said pulses of each said pulse pair being spaced from one another a distance, in time, substantially equal to that of the known refractory period of said preselected nerve fibers to be stimulated, and each pulse of each said pulse pair of said series of pulse pairs occurring so as to be timewise spaced from each corresponding pulse of each adjacent pulse pair a distance less than the timewise occurrence of said enhanced excitability condition of said preselected nerve fibers to be stimulated;

first and second electrodes; and

coupling means connected with said generating means and said first and second electrodes to apply said series of output pulse pairs to said preselected nerve fibers through said first electrode and to apply said series of output pulse pairs in inverted polarity to said preselected nerve fibers through said second electrode so that said applied positive pulse of each said pulse pair sets said preselected nerve fibers, and so that said later occurring applied negative pulse of each said pulse pair occurs substantially at the end of said refractory period to excite said preselected nerve fibers, whereby said first and second electrodes are both made active to promote stimulation of said preselected nerve fibers and thereby increase the activity thereof.

2. The device of claim 1 wherein said preselected nerve fibers have a maximum hyperexcitability condition, and wherein said generating means includes means to repeatedly provide said series of pulse pairs such that each said corresponding pulse of each pulse pair occurs with a timewise spacing less than but based upon that of the known time between said action potential and said maximum hyperexcitability condition of said preselected nerve fibers.

3. The device of claim 2 wherein said generating means repeatedly generates said first and second pulse with a substantially equal pulse spacing between each said pulse generated whereby a symmetrical bi-phased waveform is provided.

4. The device of claim 1 wherein said generating means includes means providing for stimulation of at least one class of sensory, motor, pain control and autonomic nerve fibers, and wherein said first and second electrodes are made substantially equally active to stimulate said nerve fibers selected for stimulation.

5. The device of claim 1 wherein said generating means includes digital means for causing generation of said series of first and second pulses.

6. The device of claim 5 wherein said digital means includes digital counter means and decoding logic means.

7. The device of claim 6 wherein said decoding logic means generates a plurality of timewise spaced pulses for providing said series of output pulses.

8. The device of claim 7 wherein said first and second electrodes establish a first output channel, wherein said device also includes third and fourth electrodes establishing a second output channel, and wherein said decoding logic means provides timewise spaced pulses for separate application to each of said electrodes.

9. The device of claim 1 wherein said generating means includes means providing for stimulation of pain reduction neurons by causing said spacing between each of said first and second pulses to be between about 1700 and 2000 microseconds.

10. The device of claim 9 wherein said generating means includes means for causing said spacing between said of said first and second pulses to be about 1800 microseconds.

11. A device for providing electrical stimulation through plural active electrodes to preselected nerve fibers having known refractory periods and enhanced excitability conditions that occur following the occurrence of an action potential, said device comprising:

generating means for generating a series of output pulse pairs each having first and second pulses with said first pulse of each said pulse pair being a positive polarity pulse and said second pulse of each said pulse pair being a negative polarity pulse, said first and second pulses of each said pulse pair and each said second pulse and the timewise adjacent first pulse of a succeeding pulse pair being spaced, in time, from one another a distance substantially equal to the known refractory period of said preselected nerve fibers;

first and second electrodes; and

coupling means connected with said generating means and said first and second electrodes to receive said pulses from said generating means and to apply said pulses to said preselected nerve fibers through said first electrode and to apply said pulses in inverted polarity to said preselected nerve fibers through said second electrode so that said first pulse of each said pulse pair acts through said first electrode to set said preselected nerve fibers and said second pulse of each said pulse pair acts through said first electrode substantially at the end of said refractory period for said preselected nerve fibers to excite said preselected nerve fibers, and so that said inverted second pulse of each said pulse pair acts through said second electrode to set said preselected nerve fibers and said inverted first pulse of each succeeding pulse pair acts through said second electrode substantially at the end of said refractory period for said preselected nerve fibers to excite said preselected nerve fibers, whereby both said first and second electrodes are substantially equally active to enhance stimulation of said preselected nerve fibers.

12. The device of claim 11 wherein said generating means includes digital means for generating each of said pulses.

13. The device of claim 12 wherein said first and second electrodes establish a first delivery channel, wherein said device includes third and fourth electrodes establishing a second delivery channel, and wherein said generating means provides said pulse pairs to said coupling means such that each pulse is timewise offset with respect to each corresponding pulse so that said pulse pairs coupled to said first and second delivery channels are offset with respect to one another.

14. A method for enhancing electrical stimulation through plural active electrodes of nerve fibers having predetermined refractory periods and enhanced excitability conditions that occur during known periods following the occurrence of an action potential, said method comprising:

generating a first pulse of positive polarity and applying said first pulse through a first electrode to nerve fibers to be electrically stimulated to thereby set said nerve fibers;

generating a second pulse of negative polarity and applying said second pulse through said first electrode to said nerve fibers to be electrically stimulated to cause excitation thereof, with said second pulse being generated at a time subsequent to said first pulse that is substantially equal to that of the refractory period for said nerve fibers then to be stimulated;

repeatedly generating said first and second pulses with each occurrence of each said first pulse being timewise spaced from each adjacent preceding second pulse a distance that is substantially equal to that of the refractory period for said nerve fibers with the spacing between corresponding adjacent ones of said first and second pulses being sufficiently near to the timewise occurrence of said enhanced excitability condition of said preselected nerve fibers to be stimulated to enhance stimulation of said nerve fibers;

inverting said second pulse and applying said resulting positive pulse through said second electrode to said nerve fibers to be stimulated to thereby set said nerve fibers; and

inverting said next occurring first pulse and applying said resulting negative pulse through said second electrode to said nerve fibers to be stimulated to cause excitation thereof.

15. The method of claim 14 wherein said nerve fibers then to be stimulated have a maximum hyperexcitability condition, and wherein said first and second pulses are repeatedly generated so that said negative pulses coupled through said first and second electrodes occur sufficiently close to a time substantially corresponding to the known time of occurrence of said maximum hyperexcitability condition of said nerve fibers to thereby excite said nerve fibers.

16. The method of claim 14 wherein said method includes generating said first and second pulses by digital circuitry.

17. The method of claim 16 wherein said first and second pulses are applied to a third electrode timewise after said corresponding pulses are applied to said first electrode, and wherein said inverted first and second pulses are applied to a fourth electrode timewise after said corresponding pulses are applied to said second electrode, with said first and second electrodes providing a first pulse delivery channel and said third and fourth electrodes providing a second pulse delivery channel.

18. The method of claim 16 wherein said pulse pairs acting through said first and second electrodes stimulate one of sensory, motor, pain control, and autonomic fibers.