Test strip having a non-particulate dialyzed polymer layer

• US 4,814,142 A
• Filed: 05/22/1987
• Issued: 03/21/1989
• Est. Priority Date: 05/22/1987
• Status: Expired due to Term

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Polymer Technology Group, Inc. (DSM-Firmenich AG)
• Inventors: Gleisner, John M.
• Primary Examiner(s): Richman, Barry S.
• Assistant Examiner(s): ALEXANDER, LYLE
• Application Number:
  US07/053,079
• Time in Patent Office: 669 Days
• Field of Search: 422/55-58, 436/169-170, 436/64
• US Class Current: 422/421
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: G01N 33/525 Multi-layer analytical elements
• CPC Class Codes: Y10T 436/104998 Glucose, ketone, nitrate standard or control

Abstract

A diagnostic test strip for the detection of a analyte in a test fluid. The test strip has a reagent layer on a support layer. The reagent layer contains an analyte detection system in a non-particulate dialyzed latex polymer.

Claims

1. A diagnostic test strip for the detection of a predetermined substance in a fluid wherein the strip comprises a support having thereon a reagent layer wherein the reagent layer contains a non-particulate dialyzed latex polymer and dispersed therein a reagent detection system consisting essentially of one or more reagent compositions which react with the substance to provide a detectable change, wherein the dialyzed latex polymer constitutes at least about 60% by weight of the dry reagent layer.

2. The tests strip of claim 1 wherein the dialyzed latex polymers comprises a carboxylated polyvinyl acetate/ethylene copolymer.

3. The test strip of claim 1 wherein the dialyzed latex polymer constitutes at least about 75% by weight of the reagent layer.

4. The test strip of claim 1 wherein the dialyzed latex polymer comprises a carboxylated polyvinyl acetate/ethylene copolymer.

5. The test strip of claim 4 wherein the reagent layer contains a reagent detection system for detecting glucose.

6. The test strip of claim 5 which provides a visible change when glucose is present.

7. The test strip of claim 6 wherein the visible change is a change of color.

8. A diagnostic test strip comprising a transparent support having thereon a reagent layer comprising dialyzed non-particulate carboxylated vinylacetate/ethylene copolymer and dispersed therein a reagent detection system consisting essentially of glucose oxidase, peroxidase, and a color indicator that changes color when exposed to glucose, wherein the dialyzed latex copolymer constitutes at least about 60% by weight of the dry reagent layer.