Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins
First Claim
1. A drug-delivery device for the controlled release of therapeutically active ingredient into an environment of use which comprises:
- (A) a core composition comprising(a) a water insoluble, non-diffusible charged resin entity, and(b) a diffusible water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and
(B) a substantially imperforate water insoluble wall surrounding said core composition and prepared from a semipermeable material substantially impermeable to core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a means for release of the therapeutic agent through the water insoluble wall.
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Abstract
The instant invention is directed to a drug delivery device for the controlled release of beneficial agents and drugs into an environment of use comprising:
(A) a core composition comprising
(a) a water insoluble, non-diffusible charged resin entity, and
(b) a diffusible, water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and
(B) a substantially imperforate water-insoluble wall surrounding said core composition, prepared from a semipermeable material substantially impermeable to the core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a hole(s) for release of the therapeutic agent through the water insoluble wall.
105 Citations
20 Claims
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1. A drug-delivery device for the controlled release of therapeutically active ingredient into an environment of use which comprises:
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(A) a core composition comprising (a) a water insoluble, non-diffusible charged resin entity, and (b) a diffusible water soluble ionizable therapeutically active ingredient carrying the same charge as said resin entity; and (B) a substantially imperforate water insoluble wall surrounding said core composition and prepared from a semipermeable material substantially impermeable to core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a means for release of the therapeutic agent through the water insoluble wall. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification