Thyronine derivatives

• US 4,814,484 A
• Filed: 01/07/1987
• Issued: 03/21/1989
• Est. Priority Date: 01/09/1986
• Status: Expired due to Fees

• Current Assignee: CIS Bio International (Institut National Radio-Elements et D'Util Pub)
• Original Assignee: Hoechst Aktiengesellschaft (Sanofi )
• Inventors: Strecker, Helmut, Hachmann, Henning, Simons, Guido, Wissmann, Hans
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/001,207
• Time in Patent Office: 804 Days
• Field of Search: 424/1.1, 560/39, 260/502.5 D
• US Class Current: 560/39
• CPC Class Codes: C07F 9/301 Acyclic saturated acids which can have further substituents on alkyl
• CPC Class Codes: C07F 9/3808 Acyclic saturated acids which can have further substituents on alkyl
• CPC Class Codes: G01N 33/78 Thyroid gland hormones , e.g. T3, T4, TBH, TBG or their receptors

Abstract

The invention relates to new thyronine derivatives of the formula ##STR1## in which n is 1-6, R denotes hydroxyl, alkyl or aryl, R¹ and R² are identical or different and denote iodine or hydrogen, and R³ denotes hydrogen, alkyl or aralkyl, a process for the preparation thereof, and the use thereof for carrying out radioimmunoassays.

Claims

1. A compound of the formula I, ##STR5## in which n represents an integer between 1 and 6,

R denotes hydroxyl, (C₁ -C₆)-alkyl or (C₆ -C₁₀)-aryl,

R¹ and R² are identical or different and denote iodine or hydrogen, and

R³ denotes hydrogen, (C₁ -C₆)-alkyl or (C₇ -C₁₀)-aralkyl, and the salts thereof.

2. A compound of the formula I as claimed in claim 1, in which

n is 1 to 4,

R denotes hydroxyl or (C₁ -C₄)-alkyl, and

R³ denotes hydrogen or (C₁ -C₄)-alkyl.

3. A compound of the formula I as claimed in claim 1, in which R³ denotes hydrogen, methyl or ethyl.

4. A compound of the formula I as claimed in claim 1, in which at least one of the iodine atoms is radioactively labeled as ¹²⁵ I.