Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member

• US 4,815,449 A
• Filed: 03/30/1987
• Issued: 03/28/1989
• Est. Priority Date: 11/21/1984
• Status: Expired due to Term

• Current Assignee: Bruce S. Horowitz
• Original Assignee: Bruce S. Horowitz
• Inventors: Horowitz, Bruce S.
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Hanley, John C.
• Application Number:
  US07/031,885
• Time in Patent Office: 729 Days
• Field of Search: 128/1.1, 128/1.2
• US Class Current: 600/7
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61N 2005/1012 Templates or grids for guiding the introduction of sources
• CPC Class Codes: A61N 2005/1023 Means for creating a row of seeds, e.g. spacers
• CPC Class Codes: A61N 2005/1024 Seeds
• CPC Class Codes: A61N 5/1001 using radiation sources introduced into or applied onto the body; brachytherapy
• CPC Class Codes: A61N 5/1014 Intracavitary radiation therapy
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

A delivery system for interstitial radiation therapy comprising a substantially non-deflecting elongated member of material which is absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the member. In one form, the member comprises an elongated member having the seeds longitudinally spaced therein and forming a needle that can be inserted in the tumor to be treated.

Claims

1. A delivery system for interstitial radiation therapy comprising:

an integral elongated member made from a material which is absorbable in living tissue, said member having a length substantially greater than its width, and a plurality of radioactive sources predeterminedly dispersed longitudinally in said member, said member having sufficient rigidity to be driven into a tumor without deflection to provide for controlled and precise placement of the radioactive sources in the tumor, said integral elongated member comprising;

a tapered tip at one end thereof; and

,

a plurality of visibly identifiable and physically defined segments, a subgroup of said plurality of segments encasing said plurality of radioactive sources, each segment of said subgroup containing a corresponding radioactive source of said plurality of radioactive sources, said plurality of segments defining said integral elongated member with said tip at one end of said member.

2. The delivery system set forth in claim 1 wherein said elongated member is made from a copolymer of lactide and glycolide.

3. The delivery system set forth in claim 2 wherein said segments are delineated by circumferential grooves about said elongated member.

4. The delivery system for interstitial radiation therapy comprising:

an elongated member made from a material which is absorbable in living tissue, said member having a length substantially greater than its width, and a plurality of discrete radioactive sources predeterminedly dispersed along the length of said member, said elongated member having sufficient rigidity to be driven into a tumor without deflection to provide for controlled and precise placement of the discrete radioactive sources in the tumor wherein said elongated member comprises a hollow tube of absorbable material having said plurality of discrete radioactive sources dispersed therein and longitudinally spaced therealong by a plurality of spacers of absorbable material disposed in said tube between one or more of said plurality of discrete radioactive sources to obtained a fixed linear positioning of all of said plurality of radioactive sources wherein said tube has a characteristic that maintains the tube'"'"'s integrity and the fixed linear positioning at said plurality of radioactive sources for a first predetermined period of time subsequent to an implantation into said living tissue and wherein said tube has a further characteristic such that the tube is substantially absorbed by said living tissue over a second predetermined period of time that is longer than said first predetermined period of time.

5. The delivery system set forth in claim 4 wherein said hollow tube has a tapered end.

6. The delivery system set forth in claim 4 wherein each one of said plurality of discrete radioactive sources comprise a seed that defines an encapsulated discrete radioactive source.