Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation
First Claim
1. A biologically compatible multi-layered in vivo implantation material comprisinga porous, luminal layer of poly(tetrafluoroethylene) anda second layer comprising a porous mixture of poly(tetrafluoroethylene) and elastomer.
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Accused Products
Abstract
Biologically compatible materials capable of being formed into implants, comprising layers of poly(tetrafluoroethylene) and mixtures of poly(tetrafluoroethylene) and elastomer, having excellent compliance, strength, elasticity and suturability are disclosed. The materials are preferably prepared as implants or vascular grafts by co-extruding a relatively thin luminal layer of poly(tetrafluoroethylene) having a distinct fibral nodal microstructure within a layer of a mixture of poly(tetrafluoroethylene) and elastomer to impart elasticity to the implant. A preferred embodiment comprises a radially asymmetric composite vascular graft having a luminal layer of poly(tetrafluoroethylene), a second layer of poly(tetrafluoroethylene)/elastomer mixture, a third layer of elastomer, and a fourth layer of a monomer fibrous elastomer matrix with each layer having a distinctive pore size, pore shape and porosity to promote tissue ingrowth and periprosthetic tissue anchoring.
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Citations
42 Claims
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1. A biologically compatible multi-layered in vivo implantation material comprising
a porous, luminal layer of poly(tetrafluoroethylene) and a second layer comprising a porous mixture of poly(tetrafluoroethylene) and elastomer.
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15. The material in accordance with claim 112 in which a solvent is admixed with the elastomer and applied to the exterior surface of the second layer to form a third layer.
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38. A biologically compatible multi-layered in vivo implantation material comprising
a porous, luminal layer of poly(tetrafluoroethylene), a second layer comprising a porous mixture of poly(tetrafluoroethylene and elastomer) and a third layer comprising an elastomer applied to the exterior surface of the second layer.
- 40. A biologically compatible multi-layered in vivo implantation material comprising a porous, luminal layer of poly(tetrafluoroethylene), a second layer comprising a porous mixture of poly(tetrafluoroethylene) and elastomer, a third layer comprising an elastomer applied to the exterior surface of the second layer and a fourth layer comprising a fibrous monomer matrix applied to the exterior of the third layer.
Specification