Particle size distribution analysis

• US 4,817,446 A
• Filed: 02/13/1987
• Issued: 04/04/1989
• Est. Priority Date: 07/25/1986
• Status: Expired due to Fees

• Current Assignee: Toa Medical Electronics Co., Ltd.
• Original Assignee: Toa Medical Electronics Co., Ltd.
• Inventors: Kanamori, Shigeo
• Primary Examiner(s): NOLAND, THOMAS
• Application Number:
  US07/014,770
• Time in Patent Office: 781 Days
• Field of Search: 73/865.5, 364/555
• US Class Current: 73/865.5
• CPC Class Codes: G01N 15/01 specially adapted for biological cells, e.g. blood cells investigating sedimentation of particle suspensions in blood G01N15/05
• CPC Class Codes: G01N 15/02 Investigating particle size or size distribution by measuring osmotic pressure G01N7/10; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10
• CPC Class Codes: G01N 15/10 Investigating individual particles

Abstract

A method for measuring and analyzing particle size distribution of extremely fine particles, such as blood corpuscles and cells, comprises collecting analyzing particle size distribution from the instrument, setting an estimated distribution theoretically, comparing between the two distributions, determining the difference therebetween, and making the difference a characteristic parameter for the analyzing particle size distribution.

Claims

1. A method for measuring and analyzing particle size distribution, the method comprising:

collecting an analyzing particle size distribution of a given sample content from a particle size measuring instrument;

setting up an estimated particle size distribution as a theoretical distribution based upon portions of distributions for the given sample content particle size distribution;

comparing between the analyzing particle size distribution and the estimated particle size distribution so as to determine the difference therebetween; and

making the difference a characteristic parameter for classifying the analyzing particle size distribution according to the sample content.

2. A method as in claim 1, wherein the estimated distribution is output to an output section of an analyzing instrument simultaneously with the analyzing particle size distribution.

3. A method for measuring and analyzing particle size distribution, the method comprising:

collecting an analyzing particle size distribution of a given sample content from a particle size measuring instrument;

setting up an estimated particle size distribution as a theoretical distribution based upon portions of distributions for the given sample content particle size distribution;

comparing between the analyzing particle size distribution and the estimated particle size distribution so as to set up a classifying characteristic parameter representing the difference therebetween; and

classifying the analyzing particle size distribution according to the sample content depending upon at least one of the characteristic parameter and the type of estimated distribution.

4. A method as in claim 3, wherein the analyzing particle size distribution is compared to a plurality of estimated distributions.

5. A method as in claim 4, further including setting up said plurality of estimated particle size distributions as multiple theoretical distributions, comparing between said analyzing distributions and each of said plurality of estimated distributions to determine the difference between each of said plurality of estimated distributions and said analyzing distribution and making each difference a characteristic parameter for classifying the analyzing particle size distribution according to the sample content.

6. A method as in claim 5, wherein said setting up of said plurality of estimated particle size distributions includes setting up a given number of estimated particle size distributions as a function of said analyzing particle size distribution.

7. A method as in claim 6, wherein the estimated particle size distribution is used to obtain a characteristic parameter for classifying the collected analyzing particle size distribution.

8. A method for measuring and analyzing particle size distribution, the method comprising:

collecting an analyzing particle size distribution of a given sample content from a particle size measuring instrument;

setting up an estimated particle size distribution as a theoretical distribution;

comparing between the analyzing particle size distribution and the estimated particle size distribution so as to determine the difference therebetween;

making the difference a characteristic parameter for classifying the analyzing particle size distribution according to the sample content; and

further including setting up a plurality of estimated particle size distributions as multiple theoretical distributions, comparing between said analyzing distribution and each of said plurality of estimated distributions to determine the difference between each of said plurality of estimated distributions and said analyzing distribution and making each difference a characteristic parameter for classifying the analyzing particle size distribution according to the sample content.

9. A method as in claim 8, wherein said setting up of said plurality of estimated particle size distributions includes setting up a given number of estimated particle size distributions as a function of said analyzing particle size distribution.

10. A method for measuring and analyzing particle size distribution the method comprising:

collecting an analyzing particle size distribution from a particle size measuring instrument;

setting up an estimated particle size distribution as a theoretical distribution as a function of said collected analyzing particle size distribution;

wherein said analyzing particle size distribution includes a frequency component and a size component, said setting up of said estimated particle size distribution including;

setting up a logarithm of said frequency of said analyzing particle size distribution;

differentiating said logarithm of said frequency of said analyzing particle size distribution;

finding a linear portion of said differentiated logarithm of said frequency of said analyzing particle size distribution;

calculating a mean value and standard deviation from said linear portion; and

determining said estimated particle size distribution using said calculated mean value and said standard deviation.

11. A method as in claim 10, wherein said differentiating of said logarithm of said frequency of said analyzing particle size distribution includes determining the difference between adjacent logarithm analyzing frequency distribution values.

12. A method as in claim 10, wherein said finding of said linear portion includes applying a window to said differentiated logarithm of said frequency of said analyzing particle size distribution.

13. A method as in claim 10, further including comparing between the analyzing distribution and the estimated distribution so as to determine the difference therebetween, and making the difference a characteristic parameter for classifying the analyzing particle size distribution according to the same content.

14. A method as in claim 13, further including setting up a plurality of estimated particle size distributions as multiple theoretical distributions, comparing between said analyzing distribution and each of said plurality of estimated distributions to determine the difference between each of said plurality of estimated distributions and said analyzing distribution and making each difference a characteristic parameter for classifying the analyzing particle size distribution according to the sample content.

15. A method as in claim 14, wherein said setting up of said plurality of estimated particle size distributions includes setting up a given number of estimated particle size distributions as a function of said analyzing particle size distribution.

16. A method as in claim 15, wherein said setting up of said plurality of estimated particle size distributions includes setting up a number of estimated particle size distributions corresponding to the number of linear portions of said differentiated logarithm of said frequency of said analyzing particle size distribution.