Silk-fibroin and human-fibrinogen adhesive composition

• US 4,818,291 A
• Filed: 12/10/1987
• Issued: 04/04/1989
• Est. Priority Date: 12/10/1986
• Status: Expired due to Fees

• Current Assignee: Ajinomoto Co., Inc.
• Original Assignee: Ajinomoto Co., Inc.
• Inventors: Iwatsuki, Makoto, Hayashi, Toshio
• Primary Examiner(s): Morris, Theodore
• Application Number:
  US07/131,427
• Time in Patent Office: 481 Days
• Field of Search: 106/124, 530/353, 424/101
• US Class Current: 106/124.1
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 24/106 Fibrin; Fibrinogen
• CPC Class Codes: C09J 189/00 Adhesives based on proteins; Adhesives based on derivatives thereof

Abstract

The present invention provides a novel adhesive which contains a mixture of human-fibrinogen and silk-fibroin and which is suitable especially for use in surgery. The mixing ratio of silk-fibroin to human-fibrinogen is 5 to 90, preferably 20 to 70% by weight.

Claims

1. An adhesive comprising a mixture of human-fibrinogen and silk-fibroin.

2. An adhesive according to claim 1, wherein the content of said silk-fibroin in said mixture is 5 to 90% by weight.

3. An adhesive according to claim 1, wherein said silk-fibroin is obtained from domestic silk or wild silk, or a mixture thereof.

4. An adhesive according to claim 1, which is sterile, so that it is applicable as a surgical adhesive.