Growth hormone and thyroid hormone

• US 4,818,531 A
• Filed: 02/06/1985
• Issued: 04/04/1989
• Est. Priority Date: 02/06/1985
• Status: Expired due to Fees

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Anderson, David B., Wagner, Jack F.
• Primary Examiner(s): Griffin, Ronald W.
• Assistant Examiner(s): Moezie, F. T.
• Application Number:
  US06/698,669
• Time in Patent Office: 1,518 Days
• Field of Search: 424/111, 514/12
• US Class Current: 424/422
• CPC Class Codes: A23K 10/40 Mineral licks, e.g. salt blocks
• CPC Class Codes: A23K 20/147 Polymeric derivatives, e.g. peptides or proteins
• CPC Class Codes: A23K 20/168 Steroids
• CPC Class Codes: A23K 20/184 Hormones
• CPC Class Codes: A23K 20/20 Inorganic substances, e.g. oligoelements
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00

Abstract

This invention describes a method of increasing the feed intake of pigs, chickens, or dairy cattle, which have elevated levels of growth hormone, by administering a thyroid-active substance.

Claims

1. A method of offsetting feed intake depression in pigs attributable to exogenous administration of a growth hormone related substance, which comprises administering an effective amount of a thyroid-active substance to the pigs.

2. The method of claim 1 wherein the thyroid-active substance is iodinated casein.

3. The method of claim 2 wherein the iodinated casein is administered orally on a daily basis.

4. The method of claim 3 wherein the iodinated casein is administered through feedstuff at a rate of from 1 to 1000 ppm.

5. The method of claim 4 wherein the iodinated casein is administered at a rate of from 5 to 250 ppm.

6. The method of claim 5 wherein the iodinated casein is administered for 1 to 5 months.

7. The method of claim 1 wherein the thyroid-active substance is administered by implant.

8. The method of claim 2 wherein the growth hormone related substance is growth hormone.

9. The method of claim 8 wherein the growth hormone is recombinant growth hormone.

10. The method of claim 9 wherein the growth hormone is porcine growth hormone.

11. The method of claim 10 wherein the amount of growth hormone is from 10 to 300 mcg/kg/day.