Device for the removal of therapeutic substances locally applied for use against solid tumors

• US 4,820,261 A
• Filed: 08/19/1987
• Issued: 04/11/1989
• Est. Priority Date: 02/21/1987
• Status: Expired due to Fees

• Current Assignee: Pharma Biotechnologie Hannover GmbH
• Original Assignee: Bissendorf Peptide GmbH
• Inventors: Schmoll, Ekkehard, Schmoll, Hans-Joachim, Lax, Edmund R.
• Primary Examiner(s): Pellegrino, Stephen C.
• Application Number:
  US07/086,816
• Time in Patent Office: 601 Days
• Field of Search: 604/4-6, 604/43, 604/45, 604/96, 604/101, 604/102
• US Class Current: 604/5.01
• CPC Class Codes: A61M 1/3615 Cleaning blood contaminated by local chemotherapy of a body part temporarily isolated from the blood circuit
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 25/0108 using radio-opaque or ultrasound markers
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

A device for the removal of active substances locally applied against solid tumors consists of a catheter (1) to be positioned distally to the tumor for the collection of blood coming from the tumor, a pump (2) anda catheter (3) connected thereto and returning the blood into the body. The device is characterized in that between the two catheters (1, 3) there is present at least one container (4) capable of allowing blood to pass therethrough and containing immobilized antibodies against the applied active substance.

Claims

1. A device for removing a substance from the human circulatory system comprising (a) a first catheter having one end positionable in a blood vessel distally from a tumor for removing blood from the vessel, (b) a second catheter having one end positionable in the blood vessel for returning blood to the vessel and forming with the first catheter a double catheter along at least part of their length such that the one end of the first catheter is joined to the second catheter at a distance from the one end of the second catheter, (c) a pump connected to the first and second catheters, (d) at least one container holding immobilized antibodies to the substance and connected to the first and second catheters such that blood passes from the first catheter to the second catheter through the container, and (e) an inflatable balloon for blocking the blood vessel when inflated and located on the second catheter between the end of the first catheter and the end of the second catheter.

2. A device according to claim 1 further comprising a second balloon located on the double catheter for blocking the blood vessel.

3. Device according to claim 1, characterized in that the immobilized antibody present in the container is directed against active substances of blood cells and/or blood cell precursors.

4. Device according to claim 1, characterized in that the immobilized antibody present in the container is active against lymphokines, monokines and/or cytokines.

5. Device according to claims 1, characterized in that the immobilized antibody present in the container is directed against interferons, interleukins, colony stimulating factors, tumour necrosis factor, lymphotoxin and/or transforming growth factors.