Bio compatible and blood compatible materials and methods

• US 4,820,302 A
• Filed: 06/25/1982
• Issued: 04/11/1989
• Est. Priority Date: 04/22/1982
• Status: Expired due to Term

• Current Assignee: Sanofi S.A. (Sanofi )
• Original Assignee: Sterling Drug, Inc. (GSK plc)
• Inventors: Woodroof, E. Aubrey
• Primary Examiner(s): Apley, Richard J.
• Assistant Examiner(s): Cannon, Alan
• Application Number:
  US06/392,018
• Time in Patent Office: 2,482 Days
• Field of Search: 3/36, 3/1, 128/155, 128/156, 128/DIG. 8, 424/DIG. 13, 427/2, 435/178, 523/105, 523/111, 523/112, 523/113
• US Class Current: 623/8
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 33/0011 Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

Bio- and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing, breast prostheses and implants. Detailed procedures and various products are described.

Claims

1. An implantable breast prosthesis comprising:

a three dimensional member having an outer surface at least a portion of which is adapted to be in contact with tissue and the like in a host recipient,

at least said portion of said member having functional groups extending therefrom, said functional group being selected from the group consisting of primary and secondary amino groups,

said amino groups having attached thereto a reactive group selected from the group consisting of aldehyde and aryl-halide groups,

a biological having functional groups selected from the group consisting of primary and secondary amino groups and hydroxyl groups being coupled to said portion of said member through reaction between the functional groups of said biological and the aldehyde or aryl-halide groups attached to said primary or secondary amino groups which extend from said portion of said member, and

said biological operating to provide bio- and blood compatible qualities to said surface portion.

2. A prosthesis as set forth in claim 1 wherein said member is flexible.

3. A prosthesis as set forth in claim 2 wherein said member is flexible silicone rubber.

4. A prosthesis as set forth in claim 2 wherein said member encloses a malleable core.

5. A prosthesis as set forth in claim 2 wherein said member encloses a core of malleable material, said core of malleable material being a silicone gel.

6. A prosthesis as set forth in claim 2 wherein said biological is a collagen gelatin type A material.

7. A prosthesis as set forth in claim 2 wherein said biological is heparin.

8. A breast prosthesis as set forth in claim 2 wherein said member forms a body member, and said body member being a single lumen prosthesis.

9. A breast prosthesis as set forth in claim 2 wherein said member forms a body member, and said body member being a double lumen prosthesis.

10. A breast prosthesis as set forth in claim 2 wherein said biological is selected form the group consisting of;

gelation Type A, high molecular weight gelatin Type A and low molecular weight gelatin Type A.