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Method of preparing particles suitable for tabletting into diagnostic reagents

  • US 4,820,627 A
  • Filed: 03/24/1986
  • Issued: 04/11/1989
  • Est. Priority Date: 03/24/1986
  • Status: Expired due to Term
First Claim
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1. A process for the preparation of a completely water-soluble, solid, labile biochemical-containing diagnostic reagent, comprising the steps of:

  • (a) providing an aqueous solution of labile biochemical;

    (b) providing particulate, inert, completely water-soluble solid bulking agent;

    (c) atomizing and uniformly spraying said aqueous solution of labile biochemical in the form of fine droplets, in a small amount, over an extended time period, onto said particulate bulking agent, the latter undergoing continuous agitation while in contact with a surrounding gaseous medium, and continuously evaporating water from said aqueous solution of labile biochemical while incorporating said labile biochemical on said particulate bulking agent under conditions effective to provide uniform distribution of said labile biochemical on said particulate bulking agent and to prevent substantial agglomeration of said bulking agent or build-up of substantial wetness in said bulking agent;

    (d) drying resultant labile biochemical-coated bulking agent to the desired dryness; and

    (e) then forming resultant dried labile biochemical-coated bulking agent into a tablet suitable for a diagnostic test reagent, said tablet having a predetermined rate of dissolution.

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