Transdermal drug composition with dual permeation enhancers

• US 4,820,720 A
• Filed: 03/29/1988
• Issued: 04/11/1989
• Est. Priority Date: 08/24/1987
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Sanders, Harold F., Libicki, Shari B., Cheng, Yu-Ling, Enscore, David J.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Horne, L. R.
• Application Number:
  US07/174,932
• Time in Patent Office: 378 Days
• Field of Search: 424/448, 424/449, 514/946, 514/947
• US Class Current: 514/356
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

A dosage form that coadministers a drug and two percutaneous absorption enhancers to a defined area of the skin is described. The dosage form comprises a body that contains supplies of drug and enhancers and has a basal surface that contacts the area of skin and transmits the drug and enhancers to the area for absorption thereby.

Claims

1. A composition of matter for application to a body surface or membrane to deliver a drug at a therapeutically effective rate by permeation through a body surface or membrane comprising, in combination:

a dual permeation enhancer comprising glycerol monolaurate and ethanol, and the drug to be delivered.

2. The composition of claim 1 further comprising a carrier having said dual permeation enchancer and said drug dispersed throughout.

3. The composition of claim 2 wherein said ethanol is separate from said drug.

4. The composition of claim 3 wherein said ethanol is in a continuous ethanol phase and said glycerol monolaurate and drug are dispersed throughout a polymer matrix.

5. The composition of claim 4 wherein said continuous ethanol phase is further comprised of glycerol monolaurate.

6. The composition of claim 2 wherein said glycerol monolaurate and ethanol are separate from said drug.

7. The composition of claim 2 wherein said body surface is skin.

8. The composition of claim 1 wherein said drug is selected from the group consisting of calcium channel blockers, estradiol and its esters, ergonovine and ergot alkaloids, opiates and narcotic analgesics.

9. The composition of claim 8 wherein said drug is a calcium channel blocker.

10. The composition of claim 9 wherein said calcium channel blocker is nilvadipine.