Oligonucleotide derivatives and production thereof
First Claim
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1. An immobilized oligodeoxyribonucleotide represented by the formula:
- ##STR8## wherein B is a base residue comprising a nucleoside selected from the group consisting of adenine, guanine, cytosine and thymine;
R1 is a straight or branched divalent hydrocarbon group having 2 to 20 carbon atoms;
m is an integer from 0 to 6;
n is an integer from 0 to 40;
m+n is an integer from 1 to 46; and
wherein each B in the formula is the same or different from the other.
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Abstract
An oligonucleotide derivative having an amino group protected with an eliminatable group bonded through a phosphate group and a spacer with an appropriate length to the 5'"'"'-end of an oligonucleotide protected suitably at the 3'"'"'-hydroxyl group and the base moiety of the nucleotide, and an immobilized oligonucleotide derivative having a Sepharose carrier bonded to the amino group in place of said protective group are disclosed. Methods for production of these derivatives are also disclosed.
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Citations
4 Claims
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1. An immobilized oligodeoxyribonucleotide represented by the formula:
- ##STR8## wherein B is a base residue comprising a nucleoside selected from the group consisting of adenine, guanine, cytosine and thymine;
R1 is a straight or branched divalent hydrocarbon group having 2 to 20 carbon atoms; m is an integer from 0 to 6; n is an integer from 0 to 40; m+n is an integer from 1 to 46; and
wherein each B in the formula is the same or different from the other. - View Dependent Claims (2, 3, 4)
- ##STR8## wherein B is a base residue comprising a nucleoside selected from the group consisting of adenine, guanine, cytosine and thymine;
Specification