Novel thyronine derivatives

• US 4,820,860 A
• Filed: 08/21/1987
• Issued: 04/11/1989
• Est. Priority Date: 08/25/1986
• Status: Expired due to Term

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Hoechst Aktiengesellschaft (Sanofi )
• Inventors: Strecker, deceased, Helmut, Simons, Guido, Wissmann, Hans
• Primary Examiner(s): Lieberman, Paul
• Assistant Examiner(s): Kirschner, Helene
• Application Number:
  US07/087,805
• Time in Patent Office: 599 Days
• Field of Search: 560/40, 560/27, 562/447, 436/500
• US Class Current: 560/40
• CPC Class Codes: C08G 65/33396 having oxygen in addition to nitrogen
• CPC Class Codes: G01N 33/78 Thyroid gland hormones , e.g. T3, T4, TBH, TBG or their receptors

Abstract

The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R¹ and R² are identical or different and denote hydrogen or iodine, and R³ denotes H or alkyl, a process for the preparation of the compounds, and their use when carrying out immunoassays.

Claims

1. A compound of the formula I ##STR5## in which R denotes hydrogen, (C₁ -C₆)-alkyl or a radical of the formula ##STR6## R¹ and R² are identical or different and denote iodine or hydrogen,

R³ denotes hydrogen or (C₁ -C₆)-alkyl, and

n represents an integer between 10 and 400,

and the physiologically acceptable salts thereof with cations.

2. A compound of the formula I as claimed in claim 1, in which n is 35-70, R denotes H or (C₁ -C₄)-alkyl, and R³ denotes hydrogen or (C₁ -C₄)-alkyl.

3. A compound of the formula I as claimed in claim 1, in which R³ denotes hydrogen, methyl or ethyl.

4. A compound of the formula I as claimed in claim 1, in which at least one of the iodine atoms is radioactivately labeled.

5. A compound of the formula I, in which R¹, R², R³ and n are as defined in claim 1 and R is a radical of the formula ##STR7## and the physiologically acceptable salts thereof with cations.

6. A method of carrying out an immunoassay which comprises using in said immunoassay an effective amount of a compound of the formula I as claimed in claim 1.

7. A composition containing a mixture of two or more compounds of the formula I as claimed in claim 1.

8. A method of carrying out an immunoassay which comprises using in said immunoassay an effective amount of a composition as claimed in claim 7.