Transdermal detection system
First Claim
1. An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprisingdetector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject;
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Accused Products
Abstract
A transdermal detection system for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion comprises detector means and attachment means. The detector means includes at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the skin surface of the subject to produce a detectable signal, and a barrier means for substantially preventing migration of the detector chemical into the skin surface of the subject. The attachment means maintains the detector means adjacent the surface of the skin of the subject.
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Citations
26 Claims
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1. An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising
detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; - and
attachment means for maintaining the detector means adjacent the surface of the skin of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising
detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce an optically detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; - and
attachment means for maintaining the detector means adjacent the surface of the skin of the subject. - View Dependent Claims (18)
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19. An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising
detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal, said detector chemical being selected from chemical reagents, antibodies, enzymes and biological receptors contained in solution in a solvent and including an oxidase in solution in a solvent, and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; - and
attachment means for maintaining the detector means adjacent the surface of the skin of the subject. - View Dependent Claims (20)
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21. An apparatus for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising
detector means including (a) at least one detector chemical including a mixture of an oxidase and a peroxidase contained in solution in an aqueous solvent and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal and (b) a barrier means for substantially preventing said detector chemical from migrating into the skin of the subject; - and
attachment means for maintaining the detector means adjacent the surface of the skin of the subject. - View Dependent Claims (22, 23)
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24. An apparatus for the detection of ethanol which migrates to the surface of the skin of a subject by diffusion, comprising
detector means including (a) detector chemicals comprising an alcohol oxidase, horseradish peroxidase and tetramethylbenzidine contained in solution and capable of chemically reacting with the ethanol as the ethanol migrates to the surface of the skin of the subject to produce a detectable color change and (b) a barrier means for substantially preventing migration of said detector chemicals into the skin of the subject; - and
attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
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25. An apparatus for the detection of glucose which migrates to the surface of the skin of a subject by diffusion, comprising
detector means including (a) detector chemicals comprising glucose oxidase, horseradish peroxidase and tetramethylbenzidine contained in solution and capable of chemically reacting with the glucose as the glucose migrates to the surface of the skin of the subject to produce a detectable color change and (b) a barrier means for substantially preventing migration of said detector chemicals into the skin of the subject; - and
attachment means for maintaining the detector means adjacent the surface of the skin of the subject.
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26. A method for the detection of a target substance which migrates to the surface of the skin of a subject by diffusion, comprising maintaining a detector means adjacent the surface of the skin of the subject, the detector means including (a) at least one detector chemical contained in solution and capable of chemically reacting with the target substance as the target substance migrates to the surface of the skin of the subject to produce a detectable signal, and (b) a barrier means for substantially preventing migration of said detector chemical into the skin of the subject.
Specification