Method and apparatus for detecting myocardial ischemia

• US 4,821,735 A
• Filed: 02/11/1988
• Issued: 04/18/1989
• Est. Priority Date: 01/22/1986
• Status: Expired due to Term

• Current Assignee: Itamar Medical (C.M.) 1997 Ltd.
• Original Assignee: Daniel Goor, Raphael Mohr
• Inventors: Goor, Daniel, Mohr, Raphael
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/153,498
• Time in Patent Office: 432 Days
• Field of Search: 128/713, 128/668, 128/672-675, 128/677
• US Class Current: 600/526
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

An apparatus and method for detecting myocardial ischemia in a subject monitors the systemic vascular resistance of the subject and detects the presence of myocardial ischemia when the systemic vascular resistance increases by at least sixty percent over a base line value. Particular apparatus describe providing a measurement corresponding to the systemic vascular resistance of the cardiovascular system. A particular invasive pressure measuring apparatus uses a flexible catheter tube insertable into the artery of the subject and a micro-manometer embedded into the outer face of the wall of the catheter tube. The outer face of the embedded micro-manometer is directly exposed to the blood in an artery and the inner face of the embedded micro-manometer is covered by the inner face of the catheter tube wall.

Claims

1. A method for detecting myocardial ischemia in a subject comprising the steps of:

monitoring the systemic vascular resistance of the subject; and

detecting the presence of myocardial ischemia in a subject when the monitored systemic vascular resistance of the subject increases by at least 60%, thereby indicating the presence of myocardial ischemia.

2. The method according to claim 1, wherein the monitoring step comprises the steps of:

A. detecting the arterial pressure of the subject and generating in response thereto a blood pressure signal having a waveform in accordance with the detected arterial pressure;

B. differentiating said blood pressure signal to produce a dP/dt signal having a waveform varying in accordance with the rate at which the blood pressure signal varies;

C. detecting the peak of said dP/dt signal to determine the peak dP/dt;

D. determining a value which is substantially equal to the arterial pressure at the time of said peak dP/dt;

E. dividing said latter value by said peak dP/dt signal, which thereby produces a measurement corresponding to the systemic vascular resistance of said cardiovascular system.

3. The method according to claim 2, wherein the pressure of the femoral artery is detected.

4. The method according to claim 1, wherein said monitoring step includes the step of detecting the pressure of the femoral artery.

5. Apparatus for detecting myocardial ischemia in a subject comprising:

monitoring means for monitoring the systemic vascular resistance of the subject, and

indicator means for detecting the presence of myocardial ischemia in the subject increases by at least 60%, thereby indicating the presence of myocardial ischemia in the subject.

6. The apparatus according to claim 5 wherein said monitoring means comprises:

A. means for detecting the arterial pressure of the subject and for generating in response thereto a blood pressure signal having a waveform varying in accordance with the detected arterial pressure;

B. means for differentiating said blood pressure signal to produce a dP/dt signal having a waveform varying in accordance with the rate at which the blood pressure signal varies;

C. means for detecting the peak of said dP/dt signal to determine the peak dP/dt;

D. means for determining a value which is substantially equal to the arterial pressure at the time of said peak dP/dt; and

E. means for dividing said latter value by said peak dP/dt, thereby producing a measurement corresponding to the systemic vascular resistance of said cardiovascular system.