Tubular prosthesis having a composite structure
First Claim
1. A tubular prosthesis having a composite structure comprising(i) tubular polytetrafluoroethylene having a microfibrous structure comprising small nodes interconnected with fibrils and(ii) materials which can be absorbed by a living bodywherein (a) said polytetrafluoroethylene has a greater average fibril length on the outer surface than on the inner surface, and the fibrous structure of said polytetrafluoroethylene varies continuously across the thickness of the tube wall wherein said inner surface has said fibrous structure being predominantly oriented along the axial direction and said outer surface has said fibrous structure being predominantly oriented along the concentric direction;
- and (b) said materials which can be absorbed by a living body are collagen, at least one of albumin and chitosan, and heparin, and are distributed in such a manner that collagen is present only in the portion of the tube wall which is closest to the outer surface thereof or the outer surface of the tube wall while at least one of albumin and chitosan is present only in the portion of the tube wall which is closest to the inner surface thereof or the inner surface of the tube wall, and heparin is present only in the inner surface of the tube wall.
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Accused Products
Abstract
A tubular prosthesis having a composite structure comprising (i) tubular polytetrafluoroethylene having a microfibrous structure comprising small nodes interconnected with fibrils and (ii) materials which can be absorbed by a living body wherein (a) said polytetrafluoroethylene has a greater average fibril length on the outer surface than on the inner surface, and the fibrous structure of said polytetrafluoroethylene varies continuously across the thickness of the tube wall wherein said inner surface has said fibrous structure being predominantly oriented along the axial direction and said outer surface has said fibrous structure being predominantly oriented along the concentric direction; and (b) said materials which can be absorbed by a living body are collagen, at least one of albumin and chitosan, and heparin, and are distributed in such a manner that collagen is present in the portion of the tube wall which is closest to the outer surface thereof while at least one of albumin and chitosan is present in the portion of the tube wall which is closest to the inner surface thereof, and heparin is present in the inner surface of the tube wall.
109 Citations
10 Claims
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1. A tubular prosthesis having a composite structure comprising
(i) tubular polytetrafluoroethylene having a microfibrous structure comprising small nodes interconnected with fibrils and (ii) materials which can be absorbed by a living body wherein (a) said polytetrafluoroethylene has a greater average fibril length on the outer surface than on the inner surface, and the fibrous structure of said polytetrafluoroethylene varies continuously across the thickness of the tube wall wherein said inner surface has said fibrous structure being predominantly oriented along the axial direction and said outer surface has said fibrous structure being predominantly oriented along the concentric direction; - and (b) said materials which can be absorbed by a living body are collagen, at least one of albumin and chitosan, and heparin, and are distributed in such a manner that collagen is present only in the portion of the tube wall which is closest to the outer surface thereof or the outer surface of the tube wall while at least one of albumin and chitosan is present only in the portion of the tube wall which is closest to the inner surface thereof or the inner surface of the tube wall, and heparin is present only in the inner surface of the tube wall.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
Specification
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- Resources
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Current AssigneeSumitomo Electric Industries Limited (Sumitomo Corporation)
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Original AssigneeSumitomo Electric Industries Limited (Sumitomo Corporation)
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InventorsOkita, Koichi, Kashiwagi, Tohru, Yamada, Katsuya, Okabe, Kazuhiro, Asako, Shigeru
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Primary Examiner(s)Apley, Richard J.
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Assistant Examiner(s)NOT, DEFINED
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Application NumberUS06/945,971Time in Patent Office846 DaysField of Search623/1, 623/11, 623/15, 623/16, 623/66, 623/12, 128/156, 264/288.8, 264/127US Class Current623/23.71CPC Class CodesA61F 2/06 Blood vesselsA61L 27/16 obtained by reactions only ...A61L 27/34 Macromolecular materialsC08L 27/18 Homopolymers or copolymers ...C08L 5/08 Chitin; Chondroitin sulfate...C08L 5/10 Heparin; Derivatives thereofC08L 89/00 Compositions of proteins; C...
