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Method for the prevention of restenosis

  • US 4,824,436 A
  • Filed: 04/21/1987
  • Issued: 04/25/1989
  • Est. Priority Date: 04/09/1985
  • Status: Expired due to Fees
First Claim
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1. A method for inhibiting the proliferation of arterial smooth muscle cells following angioplasty which comprises the steps of:

  • 1. Conducting an angioplasty using a catheter with an expansible balloon to expand at least a portion of a plaque body and removing the catheter,2. Inserting into the artery a catheter comprising a main catheter body having means including two spaced balloon elements adapted to be positioned ajacent respective proximate and distal ends of the original site of the plaque body and to hold said main catheter body in place and expansible against the arterial walls for providing a chamber about said site, and means carried by said main catheter body for delivering heparin into said chamber,3. Inflating said two spaced balloon elements, to form a chamber at the site of the angioplasty,4. Delivering heparin into said chamber through said heparin delivering means under a pressure of 200 to 1000 mmHg at the site of the angioplasty whereby the heparin sticks to and penetrates the adjacent arterial tissue defined by the chamber,5. Deflating said two spaced balloon elements, and6. Removing the catheter from the artery.

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