Ethylene oxide monitoring device

• US 4,826,772 A
• Filed: 04/01/1987
• Issued: 05/02/1989
• Est. Priority Date: 04/08/1986
• Status: Expired due to Fees

• Current Assignee: Graphic Controls Canada Limited
• Original Assignee: Graphic Controls Canada Limited
• Inventors: Meathrel, William G.
• Primary Examiner(s): Richman, Barry S.
• Assistant Examiner(s): WARDEN, JILL ALICE
• Application Number:
  US07/033,587
• Time in Patent Office: 762 Days
• Field of Search: 436/1, 436/93, 422/58, 422/57
• US Class Current: 436/93
• CPC Class Codes: G01N 31/226 for investigating the degree of sterilisation
• CPC Class Codes: Y10T 436/142222 Hetero-O [e.g., ascorbic acid, etc.]

Abstract

Monitoring exposure to ethylene oxide using a dosimeter or monitoring device avoids using devices that collect a sample for future testing or devices that must be sent away for lab analysis. The device comprises a reactive coating including a layer of activated alumina particles coated with p-nitrobenzyl pyridine and ammonium chloride, and is adapted to instantly produce a color intensity change directly related to the dosage of the reactive coating to ethylene oxide upon the addition of a developer.

Claims

1. An ethylene oxide monitoring device comprising a reactive coating sensitive to ethylene oxide on an impermeable substrate, the reactive coating including a layer of activated alumina particles, coated with p-nitrobenzyl pyridine and ammonium chloride, adapted to instantly produce a color intensity change directly related to the exposure of the reactive coating to ethylene oxide upon addition of a developer, the color intensity change indicating an exposure sensitivity less than one ppm for an eight hour time weighted average.

2. The monitoring device according to claim 1 including color comparison means to compare color of developed reactive coating therewith to determine ethylene oxide dosage.

3. The monitoring device according to claim 1 in the form of a badge for attachment to a person.

4. The monitoring device according to claim 1 wherein the p-nitrobenzyl pyridine in an acetone solution is added to the coating prior to commencing to measurement weighted average ethylene oxide dosage.

5. The monitoring device according to claim 4 including a chemical thermal paper strip on the device which changes color when the p-nitrobenzyl pyridine in an acetone solution is added to show that the device has been activated to measure time weighted average ethylene oxide dosage.

6. The monitoring device according to claim 1 including a squeezable reservoir in the device, the reservoir containing the developer with a channel to the reactive coating.

7. The monitoring device according to claim 6 wherein the p-nitrobenzyl pyridine solution is contained in a squeezable reservoir with a channel to the reactive coating.

8. The monitoring device according to claim 1 wherein the reactive coating has a pH in the approximate range of 3 to 6 before application of the developer.

9. The monitoring device according to claim 8 wherein the reactive coating comprises a layer of activated alumina particles, coated with polyvinyl alcohol, ammonium chloride and water together with p-nitrobenzyl pyridine in a solvent solution.

10. The monitoring device according to claim 8 wherein the reactive coating comprises a layer of activated alumina particles, coated with polyvinyl alcohol;

an acid selected from the group consisting of hydrochloric acid, nitric acid and sulphuric acid; and

water together with p-nitrobenzyl pyridine in a solvent solution.

11. The monitoring device according to claim 8 wherein the reactive coating comprises a layer of activated alumina particles, coated with polyvinyl alcohol;

mineral acid;

chloride salt and water together with p-nitrobenzyl pyridine in a solvent solution, the reactive coating having a pH in the approximate range of 3.0 to 6.0 before addition of the developer.

12. The monitoring device according to claim 1 wherein a permeable attenuating barrier is provided over the reactive coating.

13. The monitoring device according to claim 12 wherein the permeable attenuating barrier is a microporous polypropylene film.

14. The monitoring device according to claim 12 wherein a foam layer is positioned between the reactive coating on the impermeable substrate and the permeable attenuating barrier, and a cavity is provided in the foam layer between the permeable attenuating barrier and the reactive coating.

15. The monitoring device according to claim 14 including a removable impermeable cover placed over the permeable attenuating barrier to seal the reactive coating before exposure.

16. The monitoring device according to claim 14 wherein a first squeezable reservoir containing the p-nitrobenzyl pyridine solution is located in the foam layer, having a first channel to the reactive coating, and a second squeezable reservoir containing the developer is located in the foam layer, having a second channel to the reactive coating.

17. The monitoring device according to claim 1 wherein the reactive coating comprises a layer of activated alumina particles, coated with polyvinyl alcohol, ammonium chloride and water together with p-nitrobenzyl pyridine in a solvent solution.

19. The monitoring device according to claim 17 wherein the activated alumina particles are thin layer chromatography grade.

20. The monitoring device according to claim 17 wherein the developer is an aqueous alkanolamine solution.

21. The monitoring device according to claim 17 wherein the impermeable substrate is white, has good rigidity, and is chemically inert.

22. The monitoring device according to claim 21 wherein the impermeable substrate is a white polypropylene film.

23. The monitoring device according to claim 17 wherein the developer is an aqueous alkaline solution of sodium hydroxide.

24. The monitoring device according to claim 23 wherein the sodium hydroxide is about a 3% solution and is thickened with a cellulose-type thickener.

25. The monitoring device according to claim 24 wherein the thickener is sodium carboxymethylcellulose.

18. The monitoring device according to Cl.iam 17 wherein the p-nitrobenzyl pyridine is in about 1-2% acetone solution.

26. A method of determining time weighted average ethylene oxide dosage, comprising the steps of:

exposing a reactive coating sensitive to ethylene oxide to the atmosphere, the reactive coating including a layer of activated alumina particles coated with p-nitrobenzyl pryidine and ammonium chloride, adapted to instantly produce a color intensity change directly related to the exposure of the reactive coating to ethylene oxide upon addition of a developer, the color intensity change indicating an exposure sensitivity less than one ppm for an eight hour time weighted average;

adding the developer to the reactive coating after exposure; and

comparing the color intensity of the reactive coating with a color comparison means to determine if time weighted average ethylene oxide dosage is above a predetermined level.

27. The method according to claim 26 wherein the developer is added to a portion of the reactive coating initially and the color intensity compared on the portion of the coating, the remaining portion of the coating being developed at a later time and the color intensity compared.

28. The method according to claim 26 wherein the reactive coating has a pH in the approximate range of 3 to 6 before application of the developer.

29. The method according to claim 26 wherein the reactive coating is prepared without the p-nitrobenzyl pyridine in a solvent solution and has a pH in the approximate range of 3 to 6, and the p-nitrobenzyl pyridine in a solvent solution is applied prior to exposing the reactive coating to the atmosphere for determining ethylene oxide dosage.

30. The method according to claim 26 wherein the reactive coating is covered with a permeable cover prior to exposure to the atmosphere.

31. The method according to claim 26 wherein the color comparison means is a color comparison chart and different color intensities represent different time weighted average dosage of ethylene oxide in the atmosphere.

32. The method according to claim 26 wherein the color comparison means is a meter to measure change in color and intensity of color.

33. The method according to claim 26 wherein the reactive coating is applied to an impermeable substrate which is white, has good rigidty and is chemically inert.

34. The method according to claim 33 wherein the impermeable substrate is a white polypropylene film.

35. The method according to claim 26 wherein the reactive coating comprises a layer of activated alumina particles, coated with polyvinyl alcohol, ammonium chloride and water together with p-nitrobenzyl pyridine in a solvent solution.

36. The method according to claim 35 wherein the p-nitrobenzyl pyridine is in about 1 to 2% acetone solution.

37. The method according to claim 35 wherein the activated alumina particles are thin-layer chromatography grade.

38. The method according to claim 26 wherein the developer is an aqueous alkaline solution of sodium hydroxide.

39. The method according to claim 38 wherein the sodium hydroxide is about a 3% solution and is thickened with a cellulose type thickener.

40. The method according to claim 38 wherein the thickener is a sodium carboxymethylcellulose.

41. The method according to claim 26 including covering the reactive coating with a permeable attenuating barrier before exposure to the atmosphere.

42. The method according to claim 41 wherein the attenuating barrier is a microporous polpropylene film.

43. The method according to claim 41 wherein the attenuating barrier is spaced from the reactive coating by a foam layer.