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Two-band optical comparator for use with chopped CW singlet oxygen monitor

  • US 4,827,938 A
  • Filed: 08/09/1988
  • Issued: 05/09/1989
  • Est. Priority Date: 05/21/1986
  • Status: Expired due to Fees
First Claim
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1. An apparatus for detecting singlet oxygen emission produced during photoradiation, comprising:

  • an optical excitation means for illuminating a particular portion of a medium containing a photodynamic sensitizer with chopped optical radiation of a wavelength capable of at least causing generation of emission around 1270 nm, wherein said emission includes a first emission component and a second emission component out of phase with said first emission component;

    an means for collecting emission from said medium and for sequentially and selectively transmitting a first band of emissions containing a first spectral portion of said emission adjacent to but not including the wavelength of 1270 NM, and then a second band containing a second spectral portion of said emission including said 1270 nm wavelength;

    an electro-optical means for detecting emission collected and filtered by said for collecting means, detection of emissions transmitted in said first spectral band producing a first output electrical signal responsive essentially to said the intensity of first portion of said emission, detection of emissions transmitted in said second spectral band producing a second output electrical signal responsive to the intensity of;

    said second portion of said emissions;

    a means for generating an electrical reference signal of the same frequency as said chopped optical excitation radiation,a means for adjusting the phase of said electrical reference signal until it is in phase with said first output electrical signal detected in said first band; and

    ,a signal processing means for separating said second emission component from said second output electrical signal by determining the component of said second output electrical signal in said second band that is about 90°

    out of phase with said synchronised electrical reference signal, whereby said component of said second output signal is a measure of singlet oxygen emission.

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