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Enzymatic neutralization of hydrogen peroxide

  • US 4,829,001 A
  • Filed: 11/08/1985
  • Issued: 05/09/1989
  • Est. Priority Date: 11/08/1985
  • Status: Expired due to Fees
First Claim
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1. A method for disinfecting a medical device comprising the steps:

  • (a) immersing a medical device in a hydrogen peroxide solution for a time sufficient to disinfect said device,(b) decomposing any residual hydrogen peroxide by use of a catalytically effective amount of a protein capable of decomposing hydrogen peroxide, said protein being immobilized on a composite article, comprising in sequence;

    (1) a polymeric fibrous support, wherein said support has been subjected to a surface modification treatment to provide binding sites thereon, said treatment providing a layer of inorganic oxide having a uniform thickness when dried in the range of 2 to 500 nm to provide binding sites thereon, or being a radio frequncy or microwave plasma treatment carried out at a frequency of 10 to 125 kilohertz with a power density in the range of 0.05 to 2.25 w/cm2 generated between two electrodes in a gas at a pressure in the range of 10 mtorr to 10 torr,(2) a layer of a protein immobilizer compound comprising a polymer or a silane-functional compound, and(3) a biological active protein bound to said layer of protein immobilizer compound and capable of decomposing hydrogen peroxide.

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