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Catheter tip polarographic lactic acid and lactate sensor for extended use in vivo

  • US 4,830,011 A
  • Filed: 09/30/1987
  • Issued: 05/16/1989
  • Est. Priority Date: 09/30/1987
  • Status: Expired due to Fees
First Claim
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1. An apparatus for the in vivo or in vitro measurement of concentrations of lactate, lactic acid, and derivatives thereof in blood at a specific site in a mammal body, wherein said lactate, lactic acid, or derivative thereof is reacted with an oxidase enzyme to produce pyruvate and hydrogen peroxide and said hydrogen peroxide is measured polarographically, comprising:

  • (a) a catheter;

    (b) an uncoated cathode positioned on and forming a tip of said catheter;

    (c) an anode positioned behind said cathode in spaced relation to said tip and surrounding said catheter wherein said anode and said cathode are electrically insulated from each other;

    (d) a multi-layered membrane completely surrounding said anode;

    (e) a potential source providing an electrical connection between said anode and said cathode; and

    (f) an oxidase meter connected to said potential source and adapted to detect a current produced between said anode and said cathode when said hydrogen peroxide diffuses through said membrane to contact said anode.

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