Intravascular blood parameter measurement system

• US 4,830,013 A
• Filed: 01/30/1987
• Issued: 05/16/1989
• Est. Priority Date: 01/30/1987
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Maxwell, Thomas P.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/008,937
• Time in Patent Office: 837 Days
• Field of Search: 128/633, 128/634, 128/666, 128/670, 128/656, 128/657, 128/658, 128/692, 128/691, 128/760, 128/768, 128/772, 128/664, 128/653, 128/637, 604/43, 604/44, 604/167, 604/169
• US Class Current: 600/312
• CPC Class Codes: A61B 5/02158 provided with two or more sensor elements
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

A parameter of blood is sensed in vivo with a system which includes a catheter and a probe. The catheter has a lumen extending therethrough, a proximal end, a distal end and a distal opening at the distal end. The probe includes one or more sensors at its distal end. A saline solution is introduced into the lumen so that there is an interface adjacent the distal opening of the catheter between the blood and saline solution. The probe is received within the catheter and affixed thereto. The interface is moved back and forth in the lumen to expose the sensors to blood so that they can sense the blood parameters of interest.

Claims

1. An assembly for in vivo measurement of the concentration of oxygen in blood comprising:

a fluorescent oxygen sensor means for sensing the concentration of oxygen in blood and providing a fluorescent oxygen signal in response thereto;

elongated optical transmission means optically coupled to said sensor means for transmitting the fluorescent oxygen signal from the sensor means proximally;

said sensor means being carried by a distal portion of the transmission means;

said sensor means and said transmission means being sized and adapted to be received within a blood vessel of a patient;

means for keeping the sensor means from contacting the wall of this vessel when the sensor means is within such vessel to thereby reduce the wall effect on the fluorescent oxygen signal; and

said keeping means spacing the sensor means from the wall of the vessel to allow blood to flow between the sensor means and the wall of the vessel.

2. An assembly as defined in claim 1 wherein said keeping means includes a tubular body having an opening, said sensor means being within the tubular body adjacent the opening.

3. An assembly as defined in claim 2 wherein said opening opens axially and said sensor means has a distal end within no less than 0.005 inch of said opening.

4. An assembly as defined in claim 2 including at least one radial aperture in the tubular body adjacent said opening.

5. A probe-catheter assembly comprising:

a probe including a first sensor for sensing a parameter of blood and providing a signal in response thereto and elongated transmission means for transmitting the signal from the sensor proximally, said sensor being carried by a distal portion of the transmission means;

a catheter having a lumen extending therethrough, a proximal end, a distal end and a distal opening at the distal end, a major length of said probe being receivable longitudinally in said lumen of said catheter with radial clearance to allow fluid flow therein and a length of the catheter being sized to be received within the cardiovascular system of a patient; and

means for attaching the probe to the catheter at a location adapted to be outside the cardiovascular system of the patient such that the sensor is within the lumen adjacent the distal opening.

6. A probe as defined in claim 5 wherein said transmission means includes means for transmitting light and said first sensor is an optical sensor.

7. A probe as defined in claim 5 wherein said transmission means includes means for transmitting light and said first sensor is a fluorescent sensor.

8. A probe-catheter assembly as defined in claim 5 wherein the distal opening opens axially and said sensor has a distal end within about 0.125 inch of said opening.

9. A probe-catheter assembly as defined in claim 5 including a second sensor for sensing a parameter of blood and providing a signal in response thereto, and said first and second sensors are within said lumen at different axial positions along the distal portion of the transmission means when the probe is received within the lumen.

10. A probe-catheter assembly as defined in claim 5 including at least one radial aperture in the catheter leading from said lumen adjacent the distal end of the catheter.

11. A probe-catheter assembly as defined in claim 9 wherein said transmission means includes first and second elongated optical fibers, each of said first and second optical fibers has a distal end, said first and second sensors are optical sensors carried by the first and second optical fibers, respectively, adjacent the distal ends thereof and said sensors are within the lumen when the probe is received within the lumen.

12. A probe as defined in claim 11 wherein said first and second sensors sense first and second different parameters in blood, respectively, and said first and second parameters are a blood gas and pH, respectively.

13. A probe as defined in claim 11 wherein said first and second sensors sense first and second different parameters in blood, respectively, and said first and second parameters are different blood gases.

14. A probe as defined in claim 11 wherein said first and second sensors sense oxygen and carbon dioxide and the first sensor is located proximally of the second sensor.

15. A probe-catheter assembly as defined in claim 11 wherein said first optical fiber extends distally beyond the second optical fiber whereby the first and second sensors are at different axial positions.

16. A probe-catheter assembly as defined in claim 15 wherein each of said first and second sensors is a fluorescent sensor.

17. A probe-catheter assembly as defined in claim 5 wherein said distal opening opens axially.

18. A probe-catheter assembly as defined in claim 17 wherein said probe terminates distally in said sensor and said sensor confronts said opening.

19. A probe-catheter assembly as defined in claim 5 wherein said means for attaching allows the probe to be attached to the catheter when the catheter is received within the cardiovascular system of the patient.

20. A probe-catheter assembly as defined in claim 5 wherein said means for attaching releasably attaches the probe to the catheter.

21. An assembly for in vivo measurement of the concentration of oxygen in blood comprising:

a fluorescent oxygen sensor means for sensing the concentration of oxygen in blood and providing a fluorescent oxygen signal in response thereto;

elongated optical transmission means optically coupled to said sensor means for transmitting the fluorescent oxygen signal from the sensor means proximally;

said sensor means being carried by a distal portion of the transmission means;

said sensor means and said transmission means being sized and adapted to be received within a vessel of a patient;

means for keeping the sensor means from contacting the wall of said vessel when the sensor means is within such vessel to thereby reduce the wall effect on the fluorescent oxygen signal; and

said keeping means including a catheter having a lumen extending therethrough, a proximal end, a distal end and a distal opening at the distal end, at least a portion of said transmission means being in said lumen with a radial clearance and means for attaching the transmission means to the catheter adjacent the proximal end of the catheter such that said oxygen sensor means is within the lumen adjacent the distal opening.