Adhesive composites for biomedical electrodes

• US 4,830,776 A
• Filed: 09/15/1986
• Issued: 05/16/1989
• Est. Priority Date: 09/15/1986
• Status: Expired due to Fees

• Current Assignee: EMPI Incorporated (Enovis Corp.), La Jolla Technology, Inc.
• Original Assignee: La Jolla Technology, Inc.
• Inventors: Thompson, James A.
• Primary Examiner(s): Barr, Josephine
• Application Number:
  US06/907,575
• Time in Patent Office: 974 Days
• Field of Search: 252/500, 523/122, 524/45, 524/43, 524/54, 524/55, 524/44, 524/500, 524/501, 524/502, 524/516, 524/521, 524/61, 128/640, 128/798, 128/802, 604/897
• US Class Current: 252/500
• CPC Class Codes: C09J 123/22 Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefines
• CPC Class Codes: C09J 7/10 without carriers
• CPC Class Codes: H01B 1/12 organic substances organic macromolecular compounds or compositions C08

Abstract

Electrically conductive, pressure sensitive adhesive composite formulations comprising adhesive polymers, electrically conductive quaternary ammonium polymers, electrically conductive water soluble and water swellable polymeric fillers for imparting cohesiveness to said composite, and additionally, chemical agents that retard oxidative or microbial degradation of the composite. The composite formulations yield a flexible and extensible material that is suitable as an adhesive for biological electrodes, particularly transcutaneous electrical nerve stimulation electrodes.

Claims

1. An electrical conductive, pressure sensitive adhesive composite viscoelastic film comprising:

space="preserve" listing-type="tabular">______________________________________ CHEMICALS PARTS BY WEIGHT ______________________________________ Low molecular weight 25-30 viscoelastic isobutylene polymer (molecular weight range about 50,000-56,000) High molecular weight 5.0-6 viscoelastic isobutylene polymer (molecular weight range about 57,000-68,000) Water receptive polymer 14.7-16.0 Humectant 9.7-11 Preservative 0.30-0.40 Microbialostat 0.15-0.25 Water 25-30 Quartesnary ammonium electrically 25-30 conductive polymer ______________________________________

2. The adhesive composite viscoelastic film as described in claim 1 wherein said electrically conductive quaternary ammonium polymer is polydiallyldimethylammonium chloride.

3. The adhesive composite viscoelastic film as described in claim 1 wherein said quaternary ammonium polymer is polymerized from monomers selected from the group consisting of ##STR2## wherein A and B independently represent a member selected from the class consisting of alkyl and phenyl radicals on which any substituents are selected from the group consisting of hydroxy, amido, carbo lower alkoxy, lower alkoxy, phenoxy, naphthoxy, cyano, thiophenoxy, lower alkoyl, 5- and 6-membered cycloalkyl tri (loweralkyl) ammonium lower alkyl, with, on the alkyl groupings only, a nitro group, and, on the phenyl radicals only, a halogen atom;

and taken together, A and B represent a member selected from the group consisting of

space="preserve" listing-type="equation">--CH.sub.2 --CH.sub.2 --, --CH(CH.sub.3)--, --CH═

CH--CH═

CH--, --CH═

CH--CH═

N--, and --CH═

CH--N═

CH--;

R and R'"'"' independently represent a member selected from the group consisting of hydrogen, chloro, bromo, lower alkyl, and phenyl radicals;

X represents a divalent radical of the formula

space="preserve" listing-type="equation">--CH.sub.2 --(0).sub.n --(CH.sub.2).sub.m --

Y represents a divalent radicl of the formula

space="preserve" listing-type="equation">--(CH.sub.2).sub.p --(0).sub.n --CH.sub.2 --

Z represents a divalent radical of the formula

space="preserve" listing-type="equation">--(CH.sub.2).sub.p --(0).sub.n --(CH.sub.2).sub.2 --

and;

n is one of the numbers 0 and 1;

m is one of the numbers 1 and 2; and

p is one of the numbers 2 and 3.

4. An electrically conductive, pressure sensitive adhesive composite having a formulation comprising:

space="preserve" listing-type="tabular">______________________________________ [AMOUNTS] CHEMICALS PARTS BY WEIGHT ______________________________________ Polyisobutylene 25-30 (molecular weight range about 50,000-56,000) Polyisobutylene 5.0-6 (molecular weight range about 57,000-68,000) Cross-linked sodium 14.7-16.0 carboxymethylcellulose Pectin 9.7-11 Butylated hydroxytoluene 0.30-0.40 2, 4, 4'"'"'-trichloro-2'"'"'- 0.15-0.25 hydroxydiphenyl ether [Ether 0.15-0.25] Water 25-30 quaternary ammonium 25-30 conductive polymer ______________________________________

5. The adhesive composite as described in claim 4 wherein said quaternary ammonium polymer, is polymerized from monomers selected from the group consisting of ##STR3## wherein A and B independently represent a member selected from the class consisting of alkyl and phenyl radicals on which any substituents are selected from the group consisting of hydroxy, amido, carbo lower alkoxy, lower alkoxy, phenoxy, naphthoxy, cyano, thiophenoxy, lower alkoyl, 5- and 6-membered cycloalkyl tri (loweralkyl) ammonium lower alkyl, with, on the alkyl groupings only, a nitro group, and, on the phenyl radicals only, a halogen atom;

and taken together, A and B represent a member selected from the group consisting of

space="preserve" listing-type="equation">--CH.sub.2 --CH.sub.2 --, --CH(CH.sub.3)--CH(CH.sub.3)--, --CH═

CH--CH═

CH--, --CH═

CH--CH═

N--, and --CH═

CH--N═

CH--;

R and R'"'"' independently represent a member selected from the group consisting of hydrogen, chloro, bromo, lower alkyl, and phenyl radicals;

X represents a divalent radical of the formula

space="preserve" listing-type="equation">--CH.sub.2 --(0).sub.n --(CH.sub.2).sub.m --

Y represents a divalent radicl of the formula

space="preserve" listing-type="equation">--(CH.sub.2).sub.p --(0).sub.n --CH.sub.2 --

Z represents a divalent radical of the formula

space="preserve" listing-type="equation">--(CH.sub.2).sub.p --(0).sub.n --(CH.sub.2).sub.2 --

and;

n is one of the numbers 0 and 1;

m is one of the numbers 1 and 2; and

p is one of the numbers 2 and 3.

6. A method of making an adhesive composite, comprising the steps of:

forming a mixture of 25-30 parts by weight of polyisobutylene having a molecular weight of about 50,000-56,000 and 5-6 parts by weight of polyisobutylene having a molecular weight of about 57,000-68,000, these visoelastic polymers being combined in a 6 to 1 ratio respectively;

adding 14.7-16.0 parts by weight of water receptive carboxymethylcellulose polymers and 9.7-11 parts by weight of humectants to said mixture;

mixing said mixture for a time sufficient to ensure uniform dispersion of said water receptive carboxymethylcellulose polymers and said humectant with said viscoelastic polymers;

adding 0.3-0.4 parts by weight of preservative and 0.15-0.25 parts by weight of microbial static agents to said mixture;

mixing said mixture to disperse said preservative and microbial agents throughout said mixture;

adding 25-30 parts by weight of water and 25-30 parts by weight of a quaternary ammonium electrically conductive polymer to said mixture, said water and said electrically conductive quaternary ammonium polymer being added to said mixture in four aliquots with about 45 minutes of mixing between each addition; and

mixing said mixture until said composite has a doughlike consistency.

7. A method as described in claim 6 wherein said quaternary ammonium electrically conductive polymer is polymerized monomers selected from the group consisting of:

##STR4## wherein A and B independently represent a member selected from the class consisting of alkyl and phenyl radicals on which any substituents are selected from the group consisting of hydroxy, amido, carbo lower alkoxy, lower alkoxy, phenoxy, naphthoxy, cyano, thiophenoxy, lower alkoyl, 5- and 6-membered cycloalkyl, tri (loweralkyl) ammonium lower alkyl, with, on the alkyl radicals only, a halogen atom; and

taken together, A and B represent a member selected from the group consisting of

space="preserve" listing-type="equation">--CH.sub.2 --CH.sub.2 --, --CH(CH.sub.3)--CH(CH.sub.3)--, --CH═

CH--CH═

CH--, --CH═

CH--CH═

N--, and --CH═

CH--N═

CH--;

R and R'"'"' independently represent a member selected from the group consisting of hydrogen, chloro, bromo, lower alkyl, and phenyl radicals;

X represents a divalent radical of the formula

space="preserve" listing-type="equation">--CH.sub.2 --(0).sub.n --(CH.sub.2).sub.m --

Y represents a divalent radicl of the formula

space="preserve" listing-type="equation">--(CH.sub.2).sub.p --(0).sub.n --CH.sub.2 --

Z represents a divalent radical of the formula

space="preserve" listing-type="equation">--(CH.sub.2).sub.p --(0).sub.n --(CH.sub.2).sub.2 --

and;

n is one of the numbers 0 and 1;

m is one of the numbers 1 and 2; and

p is one of the numbers 2 and 3.

8. A method as described in claim 6 wherein said humectant is selected from the group consisting of pectins, alginates, gums, and gelatins.