Method and apparatus for withdrawing, collecting and biosensing chemical constituents from complex fluids
First Claim
1. A method of sampling materials in a body fluid for analysis comprising contacting the fluid with a hollow fiber of porous semipermeable asymmetric membrane with skin on the outside, of pore size permitting flow of body fluid water and desired analate to the inside of the fiber, 2nd causing such flow whereby the fluid in the inside of the fiber is essentially in instantaneous equilbrium or equivalency with the body fluid with respect to the desired analate, and the fluid in the fiber lumen is available for analysis of the analate.
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Abstract
An anisotropic hollow fiber membrane is utilized to sample fluids for selected substances by convective flow of liquid and such substances, with conduct of the liquid to a sensor for analysis for such substances, to permit monitoring, particularly of body fluids, for such substances with short response times.
473 Citations
19 Claims
- 1. A method of sampling materials in a body fluid for analysis comprising contacting the fluid with a hollow fiber of porous semipermeable asymmetric membrane with skin on the outside, of pore size permitting flow of body fluid water and desired analate to the inside of the fiber, 2nd causing such flow whereby the fluid in the inside of the fiber is essentially in instantaneous equilbrium or equivalency with the body fluid with respect to the desired analate, and the fluid in the fiber lumen is available for analysis of the analate.
- 13. A device for sampling and analyzing complex fluids comprising a hollow membrane fiber means for contacting such complex fluids, such hollow fiber being of porous semipermeable anisotropic membrane with skin on the outside of pore size permitting flow of complex fluid water and desired analate to the inside of the fiber, whereby liquid in the fiber lumen is essentially instantaneously in equilibrium or equivalency with the complex fluid with respect to the desired analate, and flow means connecting the fiber lumen to sensing means for determination of the analate in the liquid.
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18. A method of sampling materials in a complex fluid comprising contacting the complex fluid with a filtration membrane means providing bulk solvent flow and filtrate collection for analysis of complex fluid fractions, with the membrane being an asymmetric, non-ingesting mebrane with skin on the outside contacting the complex fluid.
Specification