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Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix

  • US 4,832,953 A
  • Filed: 08/13/1987
  • Issued: 05/23/1989
  • Est. Priority Date: 08/13/1987
  • Status: Expired due to Term
First Claim
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1. A method for manufacturing delivery devices for the transdermal administration of a liquid drug capable of forming a crystalline hydrate which comprises, in combination:

  • a. forming a laminate, at least one lamina of which comprises a dispersion of said liquid drug in a nonaqueous matrix;

    b. cutting subunits forming said delivery devices from said laminate;

    c. packaging said delivery devices in sealed containers;

    d. heating said delivery devices in said containers to a temperature above the melting point of said crystalline hydrate and maintaining said delivery devices at such temperature for a time sufficient to prevent the formation of said crystalline hydrate for a substantial period of time after cooling of the subunits to ambient temperatures; and

    e. cooling the delivery devices to ambient conditions.

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