Method of producing a multilayered prosthesis material and the material obtained
First Claim
1. A method of producing a multilayered prosthesis material for use with a living body, said material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility, said method comprising the steps of(a) preparing a solution of a biocompatible polymer using a mixed solvent, the mixed solvent including as a first constituent a solvent in which said polymer is substantially dissolvable and as a second constituent a non-solvent in which said polymer is not substantially dissolvable, said solvent and said non-solvent being substantially miscible, and said solution being near the precipitation point of said polymer;
- (b) applying said solution to a substrate, thereby forming a coating of said solution on said substrate;
(c) precipitating the polymer in said coating by evaporating only a portion of the solvent, the amount of evaporation being such that said solution reaches the precipitation point of said polymer, the precipitate forming a physically stable porous structure, and(d) repeating steps (a), (b) and (c) in sequential fashion to form a plurality of coatings on said substrate, thereby forming the multilayered prosthesis material, said material being usable as a prosthesis when removed from said substrate.
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Accused Products
Abstract
A method of producing a mono- or multilayered prosthesis material for use with a living body, the material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility, the method comprising the steps of:
(a) preparing a polymer solution using a mixed solvent, the solution being near its precipitation point;
(b) coating a substrate and precipitating thereon the polymer to form a physically stable porous structure by evaporating at least part of the solvent fraction of the mixed solvent;
and the multilayered prosthesis material prepared by the method.
46 Citations
10 Claims
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1. A method of producing a multilayered prosthesis material for use with a living body, said material showing mechanical compliance vis-a-vis soft body tissue and possessing biocompatibility, said method comprising the steps of
(a) preparing a solution of a biocompatible polymer using a mixed solvent, the mixed solvent including as a first constituent a solvent in which said polymer is substantially dissolvable and as a second constituent a non-solvent in which said polymer is not substantially dissolvable, said solvent and said non-solvent being substantially miscible, and said solution being near the precipitation point of said polymer; -
(b) applying said solution to a substrate, thereby forming a coating of said solution on said substrate; (c) precipitating the polymer in said coating by evaporating only a portion of the solvent, the amount of evaporation being such that said solution reaches the precipitation point of said polymer, the precipitate forming a physically stable porous structure, and (d) repeating steps (a), (b) and (c) in sequential fashion to form a plurality of coatings on said substrate, thereby forming the multilayered prosthesis material, said material being usable as a prosthesis when removed from said substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification