Atmospheric pressure process for preparing pure cyclic esters

• US 4,835,293 A
• Filed: 02/24/1987
• Issued: 05/30/1989
• Est. Priority Date: 02/24/1987
• Status: Expired due to Term

• Current Assignee: Ecological Chemical Products Company
• Original Assignee: E. I. du Pont de Nemours and Company (Corteva, Inc.)
• Inventors: Bhatia, Kamlesh K.
• Primary Examiner(s): Hollrah, Glennon H.
• Assistant Examiner(s): RUSSELL, MARK
• Application Number:
  US07/017,418
• Time in Patent Office: 826 Days
• Field of Search: 549/274, 549/518
• US Class Current: 549/274
• CPC Class Codes: B01J 19/1862 placed in series
• CPC Class Codes: B01J 2219/00121 by direct heating or cooling
• CPC Class Codes: C07D 319/12 not condensed with other rings

Abstract

This invention relates to an improved process for preparing highly pure cyclic esters by heating a polymer of the corresponding α-hydroxy acid or its ester or a copolymer of α-hydroxy acid or its ester and a thermally stable polyether in the presence of an inert gas at atmospheric pressure. The cyclic ester is carried from the reaction with the inert gas to a solvent system.

Claims

1. An improved process for making a highly pure cyclic ester of the form ##STR2## wherein R₁ and R₂ can be independently hydrogen or an aliphatic hydrocarbon having from I to about 6 carbon atoms by cracking a prepolymer comprising a polymer of an α

-hydroxy acid or its ester or a block copolymer of an α

-hydroxy acid or its ester on a thermally stable polyether wherein the improvement comprises cracking the prepolymer at a suitable temperature and at a pressure at or above atmospheric pressure while maintaining a sufficiently large flow of an inert gas, the inert gas being in intimate contact with the liquid prepolymer so as to create a large interfacial area between the prepolymer and the inert gas, to evolve the cyclic ester vapors.

2. The process of claim 1 comprising the further step of scrubbing the cyclic ester vapors and inert gas in a solvent.

3. The process of claim 1 wherein the temperature is from about 215°

to 290°

C. and the pressure from about 0 psig. to about 10 psig.

4. The process of claim 1 wherein the cyclic ester is glycolide or lactide.

5. The process of claim 3 wherein the temperature is from about 230°

to 260°

C. and the pressure is from about 0 psig. to about 5 psig.

6. The process of claim 4 wherein the temperature is from about 240°

to 255°

C. and the pressure is from about 0 psig. to about 10 psig.

7. The process of claim 1 wherein the inert gas flow is 5 to 30 scfm per cubic foot of prepolymer.

8. The process of claim 4 wherein the inert gas flow is 10 to 20 scfm per cubic foot of prepolymer.

9. The process of claim 7 wherein the inert gas is nitrogen.

10. The process of claim 8 wherein the inert gas is nitrogen.

11. The process of claim 2 comprising the additional step of separating the cyclic ester from the solvent.

12. The process of claim 2 wherein the solvent is a polar solvent in which the impurities are more soluble than the cyclic ester.

13. The process of claim 11 wherein the solvent is a polar solvent in which the impurities are more soluble than the cyclic ester.

14. The process of claim 12 wherein the cyclic ester is essentially insoluble in the solvent.

15. The process of claim 12 wherein the solvent is isopropyl alcohol.

16. The process of claim 13 wherein the temperature of the solvent is lower than the freezing point of the cyclic ester.

17. The process of claim 16 wherein the temperature of the solvent is between about 20°

and 45°

C.

18. The process of claim 17 wherein the cyclic ester is separated from the solvent by mechanical means.

19. The process of claim 18 wherein the mechanical means is filtration or centrifugation.