Process for producing pyrrolidone derivative
First Claim
Patent Images
1. A process for producing a pyrrolidone derivative represented by the general formula (I):
- ##STR5## wherein R is an organic residue obtained by removing hydroxy radical from a C1-10 primary alcohol, C1-10 secondary alcohol or derivative thereof, comprising;
(1) reacting 2-pyrrolidone with acetaldehyde in the presence of a catalyst which is at least one member selected from the group consisting of potassium carbonate, sodium carbonate, potassium phosphate, sodium phosphate, potassium pyrophosphate, sodium pyrophosphate, potassium silicate and sodium silicate in an amount of 0.0001 to 10 mol % of the catalyst per mole of 2-pyrrolidone, thereby obtaining N-(α
-hydroxyethyl)pyrrolidone at a temperature in the range of -10°
to 60°
C.; and
(2) reacting the thus obtained N-(α
-hydroxyethyl)pyrrolidone with a C1-10 primary alcohol, a C1-10 secondary alcohol or a derivative thereof in the presence of an acidic catalyst selected from the group consisting of an inorganic acid, sulfamic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid and an acidic ion-exchange resin used in an amount of 0.001 to 10 mol % of the acidic catalyst per mole of N-(α
-hydroxyethyl)pyrrolidone at a temperature in the range of -10°
to 100°
C.
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Abstract
Disclosed herein is a process for producing a pyrrolidone derivative represent by the general formula (I): ##STR1## wherein R is an organic residue obtained by removing hydroxy radical from a C1-10 primary alcohol, C1-10 secondary alcohol or derivative thereof, comprising (1) reacting 2-pyrrolidone with acetaldehyde in the presence of a catalyst, thereby obtaining N-(α-hydroxyethyl)pyrrolidone, and (2) reacting the thus obtained N-(α-hydroxyethyl)pyrrolidone with a primary alcohol, a secondary alcohol or a derivative thereof in the presence of an acidic catalyst to obtain the pyrrolidone derivative.
34 Citations
15 Claims
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1. A process for producing a pyrrolidone derivative represented by the general formula (I):
- ##STR5## wherein R is an organic residue obtained by removing hydroxy radical from a C1-10 primary alcohol, C1-10 secondary alcohol or derivative thereof, comprising;
(1) reacting 2-pyrrolidone with acetaldehyde in the presence of a catalyst which is at least one member selected from the group consisting of potassium carbonate, sodium carbonate, potassium phosphate, sodium phosphate, potassium pyrophosphate, sodium pyrophosphate, potassium silicate and sodium silicate in an amount of 0.0001 to 10 mol % of the catalyst per mole of 2-pyrrolidone, thereby obtaining N-(α
-hydroxyethyl)pyrrolidone at a temperature in the range of -10°
to 60°
C.; and(2) reacting the thus obtained N-(α
-hydroxyethyl)pyrrolidone with a C1-10 primary alcohol, a C1-10 secondary alcohol or a derivative thereof in the presence of an acidic catalyst selected from the group consisting of an inorganic acid, sulfamic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid and an acidic ion-exchange resin used in an amount of 0.001 to 10 mol % of the acidic catalyst per mole of N-(α
-hydroxyethyl)pyrrolidone at a temperature in the range of -10°
to 100°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- ##STR5## wherein R is an organic residue obtained by removing hydroxy radical from a C1-10 primary alcohol, C1-10 secondary alcohol or derivative thereof, comprising;
Specification
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Current AssigneeMitsubishi Kasei Corp. (Mitsubishi Chemical Group Corp.)
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Original AssigneeMitsubishi Chemical Industries Limited (Mitsubishi Chemical Group Corp.)
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InventorsMiyake, Masao, Murao, Yoshikazu
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Primary Examiner(s)Springer, David B.
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Application NumberUS07/151,589Time in Patent Office489 DaysField of Search548/551US Class Current548/551CPC Class CodesC07D 207/263 with only hydrogen atoms or...
