Method and system for automated classification of distinction between normal lungs and abnormal lungs with interstitial disease in digital chest radiographs
First Claim
1. A method for automated classification of distinction between normal and abnormal lungs with interstitial disease in digital chest radiographs, comprising:
- sampling plural regions of interest (ROIs) of a subject digital radiograph;
producing digital data indicative of the texture of each of said ROIs;
determining from the digital data of each selected ROI texture measures indicative of the lung texture of the respective ROIs;
normalizing the texture measures determined in said determining step in relation to predetermined characteristics derived from a data base of normal lungs; and
processing normalized texture measures obtained in said normalizing step to determine based on predetermined criteria whether or not a lung image of the subject digital radiograph is normal or abnormal.
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Abstract
A method and system for automated classification of distinction between normal lungs and abnormal lungs with interstitial disease, based on the analysis of predetermined physical texture measures and also on a data base for normal lungs of these texture measures. The texture measures selected are the RMS variation, R, and the first moment of power spectrum, M, for lung texture. These two texture measures are normalized by using the data base for normal lungs. A single texture index is determined from the two normalized texture measures by taking into account the distribution (or the data base) of texture measures obtained from abnormal lungs, in order to facilitate the automated classification of normal and abnormal lungs. A threshold texture index is then chosen for initial selection of "abnormal" regions of interest (ROIs), which contain a large texture index above the threshold level. The selected abnormal ROIs are then subjected to three independent tests for a (1) definitely abnormal singular pattern, (2) localized abnormal pattern for two or more abnormal clustered ROIs, and (3) diffuse abnormal pattern for more than four abnormal ROIs distributed through the lung. A chest image containing any one of these abnormal patterns is classified as showing an abnormal lung with interstitial disease.
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Citations
46 Claims
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1. A method for automated classification of distinction between normal and abnormal lungs with interstitial disease in digital chest radiographs, comprising:
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sampling plural regions of interest (ROIs) of a subject digital radiograph; producing digital data indicative of the texture of each of said ROIs; determining from the digital data of each selected ROI texture measures indicative of the lung texture of the respective ROIs; normalizing the texture measures determined in said determining step in relation to predetermined characteristics derived from a data base of normal lungs; and processing normalized texture measures obtained in said normalizing step to determine based on predetermined criteria whether or not a lung image of the subject digital radiograph is normal or abnormal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A system for automated classification of distinction between normal and abnormal lungs with interstitial disease in digital chest radiographs, comprising:
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means for sampling plural regions of interest (ROIs) of a subject digital radiograph for evaluation; means for producing digital data indicative of the texture of each of said ROIs; means for determining from the digital data of each selected ROI texture measures indicative of the lung texture of the respective ROIs; means for normalizing the texture measures determined by said determining step in relation to predetermined characteristics derived from a data base of normal lungs; and means for processing normalized texture measures obtained by said normalizing means to determine based on predetermined criteria whether or not a lung image of the subject digital radiograph is normal or abnormal. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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Specification