Conductance catheter

• US 4,840,182 A
• Filed: 04/04/1988
• Issued: 06/20/1989
• Est. Priority Date: 04/04/1988
• Status: Expired due to Term

• Current Assignee: Rhode Island Hospital
• Original Assignee: Rhode Island Hospital
• Inventors: Carlson, Drew E.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Sykes, Angela D.
• Application Number:
  US07/176,924
• Time in Patent Office: 442 Days
• Field of Search: 128/691-694, 128/713, 128/734, 128/419 PG, 128/419 D, 128/784-786
• US Class Current: 600/507
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter

Abstract

Conductance catheter apparatus for measuring the volume of a biological chamber, the apparatus including a catheter employing a plurality of electrodes along its length, the plurality including outer transmitting electrodes and intermediate potential sensing electrodes between the outer electrodes, an alternating current source connected to provide alternating currents at high and low frequencies to the outer transmitting electrodes, processing circuitry connected to the intermediate potential sensing electrodes for processing potential signals to obtain conductance signals indicating high frequency and low frequency conductance and for using the conductance signals to determine volume in a manner that excludes parallel conductance through the wall of the chamber and surrounding tissue.

Claims

1. Conductance catheter-apparatus for measuring the volume of a biological chamber having a wall, said apparatus comprising

a catheter employing a plurality of electrodes along its length, said plurality including outer drive electrodes and intermediate potential sensing electrodes between said outer electrodes,

an alternating current source connected to provide alternating currents at high and low frequencies to said outer drive electrodes, and

processing means connected to said intermediate potential sensing electrodes for processing potential signals to obtain a high-frequency conductance signal and a low-frequency conductance signal and for using said conductance signals to determine volume in a manner that excludes parallel conductance through the wall of said chamber and surrounding tissue.

2. The apparatus of claim 1 wherein said processing means includes means to determine high-frequency and low-frequency conductance signals for each segment of the chamber between adjacent intermediate electrodes.

3. The apparatus of claim 2 wherein said processing means comprises differential amplifiers connected to receive as inputs the potentials measured at adjacent intermediate electrodes, each said amplifier outputting a difference signal indicating the change in potential between electrodes.

4. The apparatus of claim 3 wherein said processing means also comprises high-pass and low-pass filters connected to receive said difference signals of said differential amplifiers and to output filtered signals.

5. The apparatus of claim 4 wherein there is a said high-pass filter and a said low-pass filter for each said differential amplifier and respective AM detectors that output amplitude signals indicating the amplitudes of said filtered signals.

6. The apparatus of claim 5 wherein said processing means comprises dividers that are each connected to receive a said amplitude signal and to output a segment conductance signal having a magnitude equal to conductance of a respective segment between adjacent electrodes.

7. The apparatus of claim 6 wherein said processing means comprises

a high-frequency summing circuit that is connected to receive and sum the segment high-frequency conductance signals of said dividers connected to said high-pass filters and to provide said high-frequency conductance signal and

a low-frequency summing circuit that is connected to receive and sum the segment low-frequency conductance signals of said dividers connected to said low-pass filters and to provide said low-frequency conductance signal.

8. The apparatus of claim 1 wherein said processing means comprises means for subtracting a first constant times said low-frequency conductance signal from said high-frequency conductance signal to obtain a first intermediate value output.

9. The apparatus of claim 8 wherein said processing means comprises means for multiplying said first intermediate value output times a second constant to obtain a second intermediate value output having a value indicating the value of a parallel conductance at one of said high and low frequencies.

10. The apparatus of claim 9 wherein said processing means comprises means for subtracting said second intermediate value output from a said high-frequency conductance signal or low-frequency conductance signal.

11. A method of measuring the volume of a biological chamber having a wall, said method comprising

placing a catheter employing a plurality of electrodes along its length in said biological chamber, said plurality including outer drive electrodes and intermediate potential sense electrodes between said outer electrodes,

applying alternating currents at high and low frequencies to said outer drive electrodes,

processing potential signals provided by said sense electrodes to obtain a high-frequency conductance signal and a low-frequency conductance signal, and

using said conductance signals to determine volume in a manner that excludes parallel conductance through the wall of said chamber and surrounding tissue.

12. The method of claim 11 wherein said processing includes determining high-frequency and low-frequency conductance signals for each segment of the chamber between adjacent intermediate electrodes.

13. The method of claim 12 wherein said processing comprises providing the potentials measured at adjacent intermediate electrodes as inputs to differential amplifiers, each said amplifier outputting a difference signal indicating the change in potential between electrodes.

14. The method of claim 13 wherein said processing also comprises passing said difference signals through high-pass and low-pass filters and outputting filtered signals.

15. The method of claim 14 wherein there is a said high-pass filter and a said low-pass filter for each said differential amplifier and respective AM detectors that output amplitude signals indicating the amplitudes of said filtered signals.

16. The method of claim 15 wherein said processing comprises providing said amplitude signals to dividers that each output a segment conductance signal having a magnitude equal to conductance of a respective segment between adjacent electrodes.

17. The method of claim 16 wherein said processing comprises summing the segment high-frequency conductance signals of said dividers connected to said high-pass filters to provide said high-frequency conductance signal and summing the segment low-frequency conductance signals of said dividers connected to said low-pass filters to provide said low-frequency conductance signal.

18. The method of claim 11 wherein said using comprises subtracting a first constant times said low-frequency conductance signal from said high-frequency conductance signal to obtain a first intermediate value output.

19. The method of claim 18 wherein said using comprises multiplying said intermediate value output times a second constant to obtain a second intermediate value output having a value indicating the value of a parallel conductance at one of said high and low frequencies.

20. The method of claim 19 wherein said using comprises subtracting said second intermediate value output from a said high-frequency conductance signal or low-frequency conductance signal.