Process for preparing rapidly disintegrating granulates

• US 4,840,799 A
• Filed: 02/17/1987
• Issued: 06/20/1989
• Est. Priority Date: 02/14/1986
• Status: Expired due to Fees

• Current Assignee: Lejus Medical AB
• Original Assignee: Lejus Medical AB
• Inventors: Uvdal, Jonas P., Appelgren, Curt H., Eskilsson, Eva C.
• Primary Examiner(s): Page, Thurman K.
• Application Number:
  US07/015,011
• Time in Patent Office: 854 Days
• Field of Search: 424/489, 424/499, 424/500, 424/501, 424/502, 424/494, 424/490, 424/495, 424/497, 424/498, 424/493
• US Class Current: 424/493
• CPC Class Codes: A61K 9/1676 having a drug-free core with discrete complete coating layer containing drug adsorbates of liquid drug formulations on inert powders without simultaneous granulation step A61K9/141; with further drug-free outer coating A61K9/5078; drug conjugated to non-active particles A61K47/6921
• CPC Class Codes: A61K 9/1694 resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

The present invention relates to a process for preparing a rapidly disintegrating core granulate containing a pharmaceutically active compound, which granulate is optionally intended to be coated with a release determining coating, as well as such cores, whereby one adds a pharmaceutically active compound, optionally together with an emulsifier, to a solvent, and optionally treats the composition obtained intensively, optionally while reducing its particle size, distributes the treated composition obtained over a bed of a solid, preferably water soluble material, and dries the agglomerates thus obtained to the so as to form a rapidly disintegrating core granulate.

Claims

1. A process for the preparation of a rapidly disintegrating core comprising a pharmaceutically active compound, said process comprising adding an emulsifier/tenside having a HLB-value corresponding to the solubility characteristics of the pharmaceutically active compound in a solution or a suspension of the pharmaceutically active compound in a water:

alcohol mixture having a weight ratio of 40-80;

60-20 to form a pumpable composition, subjecting the pumpable composition to an intense treatment in an apparatus selected from the group of homogenizer, colloid mill, pearl mill, and pebble mill wherein the composition is distributed over a bed of at least one solid material having a large effective surface area and having nonbinding properties to the said pharmaceutically active compound so as to form an agglomerate, and drying the agglomerate to form a granulate having irregular or spherical form.

2. A process according to claim 1, wherein microcrystalline cellulose is part of the material in said bed and is present in an amount so as to form 2-25% of the granulate.

3. A process according to claim 1, wherein a disintegrating agent is part of the material in said bed and is present in an amount so as to form 2-25% of the granulate.

4. A process according to claim 1, wherein the pharmaceutically active compound has a solubility of less than 1000 mg per liter and is present in an amount of up to 50% of the granulate.

5. A process according to claim 4, wherein the pharmaceutically active compound is selected from the group consisting of nifedipine, nimodipine, nivadipine, nitrendipine, nisoldipine, niludipine, nicardipine, felodipine, omeprazole, spironolactone, griseofulvine, furosemide, and terbutaline.

6. A process according to claim 1, wherein the pharmaceutically active compound has a solubility of 1 to 10 grams per liter, and has an absorption window at the absorption in the gastrointestinal tract.

7. A process according to claim 6, wherein the pharmaceutically active compound is selected from the group consisting of L-dopa, riboflavin, digoxin, and digitoxin.

8. A process according to claim 1, wherein the emulsifier having a corresponding HLB-value is selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, polyoxystearate, and polyethylene glycol, and whereby the emulsifier is added in an amount of 5 to 100% of the weight of the pharmaceutically active compound.

9. A process according to claim 8, wherein the emulsifier is selected from the group consisting of sodium laurylsulphate, polyoxyethylene-polyoxypropylene copolymer, ester of polyhydroxyalcohols, macrogel esters, macrogel ethers, long chain alcohols, and macrogel-polyoxypropylene copolymer.

10. A process according to claim 1, wherein the bed is at least one solid material selected from the group consisting of mannitol, lactose, saccharose, glucose, fructose, sorbitol, xylitol, sodium phosphate, potassium phosphate, urea, citrate, and ascorbic acid wherein said material comprises at least 40% by weight of the granulate.

11. A process according to claim 10, wherein the solid material comprises 60 to 90% by weight of the granulate.

12. A process according to claim 1, wherein the solid material is selected from the group consisting of starch, calcium phosphate, and calcium citrates.

13. A process according to claim 3, wherein the disintegrating agent is selected from the group consisting of substituted hydroxypropylcellulose, carboxymethylstarch, cross-linked carboxymethylcellulose, cross-linked starch, and cross-linked polyvinylpyrrolidone in an amount of 2-15% by weight.

14. A process according to claim 1, wherein the granulate has a disintegration time of 5 to 10 minutes.

15. A process according to claim 1, wherein the solid material in the bed has a particle size of less than 500 microns.

16. A process according to claim 15, wherein said particle size is less than 250 microns.

17. A process according to claim 10, wherein the solid material in the bed has a particle size of less than 500 microns.

18. A process according to claim 11, wherein the solid material in the bed has a particle size of less than 500 microns.

19. A process according to claim 12, wherein the solid material in the bed has a particle size of less than 500 microns.

20. A process according to claim 1, wherein the emulsifier is selected from the group consisting of sodium laurylsulphate, polyoxyethylene-polyoxypropylene copolymer, ester of polyhydroxyalcohols, macrogel esters, macrogel ethers, long chain alcohols, and macrogel-polyoxypropylene copolymer.