Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents

• US 4,840,956 A
• Filed: 01/14/1988
• Issued: 06/20/1989
• Est. Priority Date: 02/18/1986
• Status: Expired due to Term

• Current Assignee: Warner-Lambert Company (Pfizer Inc.)
• Original Assignee: Warner-Lambert Company (Pfizer Inc.)
• Inventors: Hagen, Susan E., Solomon, Marjorie S., Domagala, John M., Sanchez, Joseph P.
• Primary Examiner(s): Daus, Donald G.
• Assistant Examiner(s): BERNHARDT, EMILY A
• Application Number:
  US07/144,301
• Time in Patent Office: 523 Days
• Field of Search: 596/156, 514/312
• US Class Current: 514/312
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond

Abstract

Disubstituted 7-pyrrolidinoquinoline- and -napthylridine-3-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

Claims

1. A compound having the formula ##STR5## wherein R₁ is hydrogen or alkyl of one to six carbon atoms;

R₂ is cyclopropyl;

n is zero R₃ is OR₄, in which R₄ is hydrogen or alkyl of one to six carbon atoms;

Ar is phenyl, or a pharmaceutically acceptable acid addition or base salt thereof.

2. A compound according to claim 1, wherein R₁ is hydrogen;

3. A compound according to claim 2 and being 1-cyclopropyl-6,8-defluoro-1,4-dihydro-7-[(3-hydroxy-3-phenyl)-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid.

4. An antibacterial composition comprising an antibacterially effective amount of a compound as claimed in claim 1 together with a pharmaceutically acceptable carrier or diluent.

5. A method of treating bacterical infections in a mammal which comprises administering to said mammal suffering therefrom an antibacterial composition as claimed in claim 4.