Collagen matrix/polymer film composite dressing

• US 4,841,962 A
• Filed: 09/11/1987
• Issued: 06/27/1989
• Est. Priority Date: 03/27/1984
• Status: Expired due to Fees

• Current Assignee: Medimatrix
• Original Assignee: Medimatrix
• Inventors: Berg, Richard A., D'Antonio, John, Pachence, James M., Silver, Frederick H.
• Primary Examiner(s): Kight, John
• Assistant Examiner(s): Nutter, Nathan M.
• Application Number:
  US07/095,779
• Time in Patent Office: 655 Days
• Field of Search: 530/356, 128/DIG. 8, 524/17, 524/21, 527/201
• US Class Current: 602/50
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61L 15/325 Collagen
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 2300/232 Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin
• CPC Class Codes: Y10S 128/08 Collagen

Abstract

A wound dressing comprising a crosslinked collagen matrix; a bioabsorbable adhesive coated on one surface of the collagen matrix; a multilayer polymer film imparting pre-selected moisture vapor and gas transmissivity to the dressing, secured to the opposite surface of the collagen matrix; and an adhesive securing the collagen matrix to the polymer film.

Claims

1. A wound dressing to promote the progressive healing of a wound comprising:

(a) a crosslinked collagen matrix;

(b) a bioabsorbable adhesive coated on the surface of the collagen matrix to be placed in contact with the wound bed whereby the matrix affords epithelial and fibroblast cells in the bed with a scaffold on which to attach themselves and grow and the adhesive facilities wound healing; and

(c) a multilayer polymer film secured to the opposite surface of the collagen matrix comprising a first layer having predetermined moisture and gas transmissivity characteristics appropriate to the wound to be healed superposed with the collagen matrix, and a second layer remote from the collagen matrix having relatively reduced moisture and gas transmissivity characteristics to render it more occlusive than the first layer to promote new cell growth in the early stages of wound healing, and strippable from the film after a period of time sufficient for the earlier stages of wound healing to take place to provide thereafter increased moisture vapor transmission between the wound bed and the atmosphere.

2. The wound dressing of claim 1, wherein the collagen matrix is formed from Type I or Type III collagen.

3. The wound dressing of claim 2, wherein the collagen matrix comprises fibers defining surface and interior pores connected by internal channels, the average pore size being from 50 to 350 microns and the collagen comprising from 2 to 30% by volume of the matrix.

4. The wound dressing of claim 1, wherein the bioabsorbable adhesive is a material selected from the group consisting of polyisobutylenes, acrylic emulsions, polyvinyl ethyl ethers admixed with hydrogenated resin esters, natural rubber latex, collagen adhesives, and water based urethane emulsions.

5. The wound dressing of claim 4, wherein the bioabsorbable adhesive is polyisobutylene containing polyacrylamides, carboxymethylcellulose, starch graft copolymers, pectins, gelatins, resin esters or hydrocarbons.

6. The wound dressing of claim 1, wherein the second polymer layer which is farthest away from the collagen matrix permits from 0 to 500 g/cm² per 24 hours moisture transmission and from 500 to 6000 cm³ m² -Atmos-24 hour oxygen permeation;

whereas the first polymer layer closest to the collagen matrix permits from 500 to 5000 g/cm² per 24 hours moisture transmission and from 6000 to 20,000 cm³ -m² - Atmos-24 hours oxygen permeation.

7. The wound dressing of claim 1, wherein the first polymer layer which is farthest away from the collagen matrix comprises a polymer selected from the group consisting of microporous polyether polyurethanes, polyester polyurethanes, microporous polyvinyl chlorides, polyolefins, cellulose acetate, polydifluroethylene, ethylene vinyl acetate, ionomeric films, silicone latex, biodegradable urethanes and acrylics;

whereas the first polymer layer closest to the collagen matrix comprises a polymer selected from the group consisting of microporous polyether polyurethanes, polyester polyurethanes, microporous polyvinylchlorides, polyolefins, cellulose acetate, polydifluoroethylene, ethylene vinyl acetate, ionomeric films, silicone latex, biodegradable urethanes and acrylics and polyisobutylenes.

8. The wound dressing of claim 1, wherein the multilayer polymer film extends beyond the periphery of the collagen matrix for securing the dressing to surrounding, non-injured skin.