Method for forming impregnated synthetic vascular grafts
First Claim
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1. A process for preparing a blood-tight collagen-impregnated synthetic vascular graft, comprising:
- providing a porous tubular flexible synthetic graft substrate;
placing an aqueous slurry of water-insoluble collagen fibrils and plasticizer onto at least the inner surface of the substrate;
massaging the substrate to insure intimate mixing of the collagen fibrils into the porous structure of the substrate;
drying the collagen;
cross-linking the collagen by exposure to formaldehyde vapor; and
vacuum drying to remove excess formaldehyde.
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Abstract
A collagen impregnated synthetic vascular graft including a synthetic vascular graft substrate and cross-linked collagen fibril is formed by depositing an aqueous slurry of collagen fibrils in the lumen of the graft and massaging to insure intimate mixing of the fibrils into the porous structure of the substrate. After massaging, the collagen is dried and cross-linked. Repeated applications and massaging and drying further reduce porosity of the graft.
202 Citations
15 Claims
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1. A process for preparing a blood-tight collagen-impregnated synthetic vascular graft, comprising:
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providing a porous tubular flexible synthetic graft substrate; placing an aqueous slurry of water-insoluble collagen fibrils and plasticizer onto at least the inner surface of the substrate; massaging the substrate to insure intimate mixing of the collagen fibrils into the porous structure of the substrate; drying the collagen; cross-linking the collagen by exposure to formaldehyde vapor; and vacuum drying to remove excess formaldehyde. - View Dependent Claims (5)
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- 2. A collagen fibril slurry for forming a blood-tight synthetic vascular graft comprising about 0.5 to 5.0 percent collagen fibril, 4.0 to 12.0 percent of a biologically compatible plasticizer and the balance water.
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6. A process for preparing a blood-type collagen-impregnated synthetic vascular graft, comprising:
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providing a porous tubular flexible synthetic graft substrate; placing a aqueous slurry of water-insoluble collagen fibrils and plasticizer onto the inner surface of the substrate; massaging the substrate to mature intimate mixing of the collagen fibrils into the porous structure of the substrate; drying the collagen; cross-linking the collagen by exposure to a biocompatible cross-linking agent; and vacuum drying to remove excess cross-linking agent. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification