Dispensing system with means for increasing delivery of beneficial agent from the system

• US 4,844,984 A
• Filed: 03/24/1988
• Issued: 07/04/1989
• Est. Priority Date: 03/19/1984
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Landrau, Felix A., Eckenhoff, James B., Cortese, Richard
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US07/173,479
• Time in Patent Office: 467 Days
• Field of Search: 424/438, 424/439, 424/469, 424/473
• US Class Current: 424/438
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0068 Rumen, e.g. rumen bolus

Abstract

A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.

Claims

1. A delivery device for delivering a beneficial agent to a ruminant, the delivery device comprising:

(a) wall means that surrounds and forms an internal lumen, said wall means comprising in at least a part a semipermeable composition permeable to fluid present in the ruminant and substantially impermeable to the passage of a beneficial agent, and wherein the lumen comprises;

(b) means for maintaining the delivery system in the environment over a period of time, said means having a density greater than the density of a fluid present in the ruminant;

(c) means for absorbing thermal energy from the ruminant for forming a dispensable composition, said means comprising a member selected from the group consisting of a glyceride of a fatty acid having a melting point of at least 31°

C., a block copolymer of 1,2-butylene oxide and ethylene oxide, a food grade wax having a melting point of at least 35°

C., a thermo-responsive lipophilic pharmaceutically acceptable carrier, a thermo-responsive hydrophobic pharmaceutically acceptable carrier, propylene glycol monostearate, propylene glycol distearate, triglyceride of saturated vegetable fatty acid, polyethylene glycol monostearate, a food grade petroleum wax, and a mixture of cocoa butter and beeswax;

(d) a beneficial agent present in the means for absorbing thermal energy;

(e) means for swelling and occupying a larger volume of the lumen for applying force against the means for absorbing thermal energy for pushing said means that absorb energy from the delivery device, said means for occupying a larger volume comprising a member selected from the group consisting of a hydrogel, poly(ethylene oxide), poly(acrylamide), poly(hydroxyalkyl acrylate), poly(acrylic acid), polysaccharide, and the sodium salt of polyacrylic acid blended with sodium chloride;

(f) means for lessening the partition of a beneficial agent from the means for absorbing thermal energy into the means for occupying a larger volume, said means for lessening the partitions located between the means for absorbing energy and the means for occupying volume; and

,

(g) at least one exit means in the wall for releasing a beneficial agent formulation from the delivery device to the ruminant over time.

2. The delivery device for delivering a beneficial agent formulation to an environment of use according to claim 1, wherein the wall means comprises a semipermeable composition that is a member selected from the group consisting of a cellulose ester, cellulose diester, cellulose triester, cellulose ether, cellulose ester-ether, cellulose acylate, cellulose diacylate, cellulose triacylate, cellulose acetate, cellulose acetate butyrate, cellulose propionate morpholinobutyrate, and cellulose acetate phthalate.

3. The delivery device for delivering a beneficial agent formulation to an environment of use according to claim 1, wherein the means for swelling and occupying volume comprises an osmotically effective solute.

4. The delivery device for delivering a beneficial agent formulation to an environment of use according to claim 1, wherein the means for lessening the partition simultaneously functions as a means for increasing the delivery of beneficial agent from the delivery device.

5. The delivery device for delivering a beneficial agent formulation to an environment of use according to claim 1, wherein the beneficial agent formulation comprises a member selected from the group consisting of mebendazole, oxfendazole, levamisole, praziquantel, morantel, pyrantel, avermectin, ivermectin, cephalosporin, sulfamethazine, sulfathiazole, dexamethazone and flumethazone.

6. The delivery device for delivering a beneficial agent formulation to an environment of use according to claim 1, wherein the means for absorbing thermal energy comprises ivermectin and the copolymer of 1,2-butylene oxide and ethylene oxide.

7. The delivery device for delivering a beneficial agent formulation to an environment of use according to claim 1, wherein the wall means comprises cellulose acetate butyrate and polyethylene glycol.