Laser-delivery eye-treatment method

• US 4,846,172 A
• Filed: 05/26/1987
• Issued: 07/11/1989
• Est. Priority Date: 05/26/1987
• Status: Expired due to Term

• Current Assignee: Michael S. Berlin
• Original Assignee: Michael S. Berlin
• Inventors: Berlin, Michael S.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): SHAY, DAVID M
• Application Number:
  US07/054,282
• Time in Patent Office: 777 Days
• Field of Search: 128/303.1, 128/395-398, 128/362
• US Class Current: 606/4
• CPC Class Codes: A61B 2018/2277 with refractive surfaces
• CPC Class Codes: A61F 2009/00868 Ciliary muscles or trabecular meshwork
• CPC Class Codes: A61F 2009/0087 Lens
• CPC Class Codes: A61F 2009/00874 Vitreous
• CPC Class Codes: A61F 2009/00887 Cataract
• CPC Class Codes: A61F 9/00802 for photoablation

Abstract

Transocular and periocular laser delivery system for treatment of eye diseases wherein a fiberoptic element is passed through a perforation made either by paracentesis of eyeball encapsulating tissue (i.e.-cornea, sclera) or by the fiberoptic element itself so that the fiber actually penetrates into a chamber therein. The penetrating fiber end is then juxtaposed to the tissue to be treated while the external fiberoptic end is coupled either to an excimer laser emitting ultraviolet radiation (in the range of 193 to 351 nanometers) or to certain lasers emitting infrared radiation, the radiated pulses therefrom being directed through the transocularly-positioned fiber to be absorbed by chromophores in the target tissue (cataractous lens, trabecular meshwork, vitreous membranes, tear duct occlusion) where removal by photoablation is effected. Photoablation by way of the fiberoptic element creates a portal for filtration of aqueous fluid in the case of glaucoma or allows removal of cataractous lens tissue, vitreous hemorrhage or membranes or other tissue occluding tear duct passages in a manner promoting controlled healing, minimizing inflammation and scarring.

Claims

1. A method for surgical treatment of the eye by laser radiation comprising the steps of:

(a) passing one end of a fiberoptic element through a small perforation in an outermost encapsulating tissue of the eyeball until said one end of said fiberoptic element penetrates into the eye'"'"'s anterior chamber,

(b) transocularly advancing said one end of the fiberoptic element through the said anterior chamber until the penetrating end of said fiberoptic element is juxtaposed immediately adjacent targeted eye tissue to be treated,

(c) coupling the opposite end of said fiberoptic element to a photoablative laser emitting radiation selected from the class consisting of (1) ultraviolet excimer radiation having a wave length of between about 193 to 351 nanometers and (2) infrared radiation having a wave length of about 2.8 to 3.0 microns and at a fluence level sufficient to produce photochemical tissue ablation and focussing the radiation being emitted from the penetrating end of the transocularly-positioned fiberoptic element upon the targeted tissue, and

(d) subjecting the adjacent targeted tissue to ablative photodecomposition from the radiation while maintaining juxtaposition of the penetrating end of said fiberoptic element to effect photochemical removal of said targeted tissue.

2. The method of claim 1 wherein the targeted tissue is intermediate an irido-corneal angle area of the eye at a level of trabecular meshwork tissue thereof.

3. The method of claim 1 wherein the tissue targeted for treatment is cataractous lens tissue.

4. The method of claim 1 including the step of aspirating and venting the anterior chamber to remove photodecomposed materials therein and irrigating said chamber in replacement of fluids aspirated therefrom.

13. The method of claim 1 wherein the photoablative laser is selected from the class emitting (1) ultraviolet excimer radiation having a wave length of between about 193 nanometers to 351 nanometers and (2) infrared radiation having a wave length between about 2.8 and 3.0 microns.

14. The method of claim 1 wherein the perforation in the outermost encapsulating tissue is made by paracentesis with a sharp pointed blade through a limbus area of cornea-sclera tissue, and the fiberoptic element is advanced through the eye'"'"'s anterior chamber and directed toward a portion of the eye'"'"'s irido-corneal angle thereof adjacent trabecular meshwork tissue therebetween to effect a trabeculectomy.

15. The method of claim 14 wherein the depth of the anterior chamber is maintained by introducing a fluid therein following paracentesis of the limbus area by the blade, and withdrawing the fiberoptic element after photoablation adjacent the trabecular meshwork.

18. The method of claim 14 including the step of evacuating products generated during photoablative decomposition by means of a cannula concentrically supported about the transocularly-positioned fiberoptic element.

19. the method of claim 14 including the step of infiltrating the anterior chamber with a fluid subsequent to paracentesis thereof.

20. The method of claim 14 wherein the photoablative laser is selected from the class consisting of ultraviolet excimer radiation having a wave length of between about 193 to 351 nanometers and infrared radiation having a wave length of between about 2.8 and 3.0 microns.

5. A method for surgical treatment of the eye by laser radiation comprising the steps of:

(a) passing one end of a fiberoptic element through a small perforation in an outermost encapsulating tissue of the eyeball thereof adjacent a limbal portion of the cornea-sclera until said one end of said fiberoptic element penetrates into the anterior chamber of the eye,

(b) transocularly advancing said one end of the fiberoptic element through the said anterior chamber until the penetrating end of said element is juxtaposed immediately adjacent eye tissue targeted for treatment,

(c) coupling the opposite end of said fiberoptic element to a photoablative laser emitting photochemical radiation above an ablative threshold fluence level to effect photochemical tissue interaction of photochemical ablation and focussing the radiation being emitted from the penetrating end of the transocularly-positioned fiberoptic element upon the targeted tissue, and

(d) then while juxtaposing the penetrating end of the fiberoptic element with the target tissue subjecting the said targeted tissue to photochemical ablative photodecomposition from the radiation being delivered through the fiberoptic element to effect photochemical removal of said targeted tissue.

6. A method for surgical treatment by laser radiation of a cataractous lens comprising the steps of:

(a) passing one end of a fiberoptic element through a small perforation in an outermost encapsulating tissue of the eye after paracentesis thereof proximate a limbal area of corneal-scleral tissue until said one end of said fiberoptic element penetrates into the anterior chamber of the eye,

(b) transocularly advancing the fiberoptic element through the anterior chamber until the penetrating end of the fiberoptic element is juxtaposed adjacent the cataractous lens targeted for treatment,

(c) coupling the exterior end of the fiberoptic element to a photoablative laser emitting radiation at an ablative fluence level sufficient to effect photochemical tissue ablation and focussing the radiation through the transocularly-positioned fiberoptic element until the emission thereof impinges directly upon the targeted cataractous lens tissue,

(d) slowly advancing the fiberoptic element as the radiation therefrom causes photoablation of the target lens tissues until photodecomposition of endocapsular tissue thereof is effected,

(e) evacuating the decomposed lens fragments and adjacent tissue while simultaneously maintaining intraocular pressure and anterior chamber depth, and

(f) withdrawing the fiberoptic element through the original perforation.

7. The method of claim 6 wherein the photoablative laser is selected from the class emitting (1) ultraviolet excimer radiation having a wave length between about 193 nanometers to 351 nanometers and (2) infrared radiation having a wave length between about 2.8 to 3.0 microns.

8. The method of claim 6 wherein the fiberoptic element utilized is selected from sizes having a diameter in the range of about 300 to 600 microns.

9. The method of claim 6 wherein the step of evacuating decomposed tissue fragments includes the step of evacuating through a concentrically disposed cannula being supported about the transocularly-positioned fiberoptic element, and having aspiration and infusion ports which communicate with an annular space therebetween.

10. A method for surgical treatment of the eye by laser radiation comprising the steps of:

(a) passing one end of a fiberoptic element through a small perforation in an outermost encapsulating tissue of the eyeball thereof until said one end of said fiberoptic element penetrates into the eye'"'"'s anterior chamber,

(b) transocularly advancing said one end of the fiberoptic element through the said anterior chamber until the penetrating end of said element is juxtaposed immediately adjacent eye tissue targeted for treatment,

(c) coupling the opposite end of said fiberoptic element to a photoablative laser emitting radiation above an ablative threshold fluence level to effect photochemical tissue interaction of photochemical ablation and focussing the radiation being emitted from the penetrating end of the transocularly-positioned fiberoptic element upon the targeted tissue, and

(d) then advancing the fiberoptic element and subjecting the targeted tissue to photochemical ablative photodecomposition from the radiation being delivered through the fiberoptic element to effect photochemical removal of said targeted tissue.

11. The method of claim 10 including the step of concurrently evacuating products generated by the photoablation while maintaining intraocular homeostasis.

12. The method of claim 11 wherein the step of evacuating products generated by the photoablative decomposition is performed through a concentrically disposed cannula supported about the transocularly-positioned fiberoptic element.

16. The method of claim 10 wherein the perforation in the outermost encapsulating tissue of the eye is made by paracentesis with a sharp pointed blade through a limbus area of cornea-sclera tissue thereof, and the fiberoptic element is directed through the eye'"'"'s anterior chamber toward lens capsule tissue to effect a lensectomy following photoablative irradiation thereof.

17. A method for surgical treatment of glaucoma by laser radiation comprising the steps of:

(a) passing one end of a fiberoptic element through a small perforation in an outermost encapsulating tissue of the eye after paracentesis thereof adjacent a limbal area of corneal-scleral tissue until said one end of said fiberoptic element penetrates into the eye'"'"'s anterior chamber,

(b) transocularly advancing the fiberoptic element through the anterior chamber until the penetrating end of said element is juxtaposed immediately adjacent tissue targeted for treatment,

(c) coupling an opposite end of the fiberoptic element to a photoablative laser emitting radiation above an ablative threshold fluence level for effecting photochemical tissue ablation and focussing the radiation thereof being delivered through the transocularly-positioned fiberoptic element for impingement directly upon the targeted tissue,

(d) maintaining juxtaposition of the fiberoptic element as the radiation emitted from the penetrating end thereof effects ablative photo-decomposition of the targeted tissue to photochemically remove said targeted tissue until sclerectomy is adequate to relieve intraocular pressure, and

(e) withdrawing the fiberoptic element through the original paracentesis to create a filtering bleb such that the eye'"'"'s sub-Tenon'"'"'s space communicates with the anterior chamber.