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Detectable molecules, method of preparation and use

  • US 4,849,208 A
  • Filed: 04/28/1987
  • Issued: 07/18/1989
  • Est. Priority Date: 01/30/1984
  • Status: Expired due to Term
First Claim
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1. An imaging procedure which comprises:

  • administering to an individual a detectable molecule of the formula A3 --(X--R1 --E--Detb)m where A3 is A2 or a polymer, both A2 and the polymer having at least one modifiable reactive group consisting of amino, hydroxy, cis OH, halide, aryl, imidazoyl, carbonyl, carboxyl, thiol or a residue comprising an activated carbon;

    A2 is a specific binding ligand having a molecular weight of less than about 2,000;

    --X-- is selected from the group consisting of ##STR52## or a C1 -C10 branched or unbranched alkyl or aralkyl, which may be substituted by --OH;

    --Y-- is a direct bond to --E--, or --Y-- is --E--R2 -- where --R2 --is a C1 -C10 branched or unbranched alkyl;

    Za is chlorine, bromine or iodine;

    --E-- is O, NH or an acyclic divalent sulfur atom;

    Detb is a metal chelator which has the formula;

    ##STR53## or the 4-hydroxy or acyloxy derivative thereof, where R3 is Cl-C4 alkyl or is --CH2--COOM, and each M is a metal or non-metal cation; and

    m is an integer from 1 to the total number of modified reactive groups on A3 ; and

    , thereafter,observing the distribution of said compound in said individual.

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