Dental preparation, article and method for storage and delivery therof

• US 4,849,213 A
• Filed: 06/19/1987
• Issued: 07/18/1989
• Est. Priority Date: 03/01/1983
• Status: Expired due to Term

• Current Assignee: Block Drug Company Incorporated (GSK plc)
• Original Assignee: Hans A. Schaeffer
• Inventors: Schaeffer, Hans A.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US07/064,880
• Time in Patent Office: 760 Days
• Field of Search: 424/499, 424/253, 424/53, 424/130
• US Class Current: 424/53
• CPC Class Codes: A61C 5/64 for multi-component compositions
• CPC Class Codes: A61K 2800/88 Two- or multipart kits
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/26 Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: B65D 35/22 with two or more compartments
• CPC Class Codes: B65D 35/242 for mixing or discharging of two or more components
• CPC Class Codes: B65D 81/325 Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents

Abstract

A composition useful in combatting gum disease including:

(a) a gel component including (i) about 0.1-10% by weight of hydrogen peroxide; (ii) about 0.05-5.0% by weight of a water-dispersible copolymer of acrylic acid cross-linked with polyallyl sucrose; (iii) about zero to about 2.0% by weight of a nonionic cellulose stabilizer; (iv) a neutralizing agent selected from the group consisting of sodium hydroxide, potassium hydroxide, triethanolamine, diisopropylamine and ammonia in an amount sufficient to raise the gel pH to about 3-6.0; and (v) purified water;

(b) a paste component including (i) about 2-60% sodium bicarbonate; (ii) about 1-6% of a salt selected from the group consisting of NaCl, MgCl₂, MgSO₄, Na₂ SO₄, and K₂ SO₄ ; (iii) about 2-60% of a humectant selected from the group consisting of glycerin, sorbitol, polyethylene glycol, propylene glycol, polypropylene glycol, an ethoxylated lower fatty alcohol, a propoxylated lower fatty alcohol and mixtures thereof; (iv) about 0.1-5% of a thickener stabilizer selected from the group consisting of cellulose gum, magnesium aluminum silicate and mixtures thereof; (v) about 1-30% of a stabilizing polishing agent selected from the group consisting of bentonite, titanium dioxide, silica, magnesium, oxide and mixtures thereof; and (vi) purified water; the paste component and gel component being combined immediately prior to use.

Claims

1. A composition useful in combatting gum disease comprising:

(a) a gel component comprising (i) about 0.1-10% by weight of hydrogen peroxide;

(ii) about 0.05-5.0% by weight of a water-dispersible copolymer of acrylic acid cross-linked with polyallyl sucrose;

(iii) about zero to about 2.0% by weight of a nonionic cellulose stabilizer;

(iv) a neutralizing agent selected from the group consisting of sodium hydroxide, potassium hydroxide, triethanolamine, diisopropylamine and ammonia in an amount sufficient to raise the gel pH to about 3-6.0; and

(v) purified water;

(b) a paste component comprising;

(i) about 2-60% sodium bicarbonate;

(ii) about 0-6% of a salt selected from the group consisting of NaCl, KCl, MgCl₂, MgSO₄, Na₂ SO₄ and K₂ SO₄ ;

(iii) about 2-60% of a humectant selected from the group consisting of glycerin, sorbitol, polyethylene glycol, propylene glycol, polypropylene glycol, an ethoxylated lower fatty alcohol, a propoxylated lower fatty alcohol and mixtures thereof;

(iv) about 0.1-5% of a thickener stabilizer selected from the group consisting of cellulose gum, magnesium aluminum silicate and mixtures thereof;

(v) about 1-30% of a stabilizing polishing agent selected from the group consisting of bentonite, titanium dioxide, silica, magnesium oxide and mixtures thereof; and

(vi) purified water;

said paste component and gel component being combined immediately prior to use.

2. The composition of claim 1, wherein said gel component comprises about 3.0-6.5% hydrogen peroxide;

about 1-3% of said copolymer; and

about 0.3-1.5% of said neutralizing agent.

3. The composition of claim 2, wherein said paste component comprises about 20-40% of said sodium bicarbonate;

about 2-4% of said salt;

about 15-255 of said humectant;

about 1.0-2.0% of said stabilizer; and

about 1.5-20% of said stabilizing polishing agent.