Antimicrobial compositions consisting of metallic silver combined with titanium oxide or tantalum oxide

• US 4,849,223 A
• Filed: 12/30/1985
• Issued: 07/18/1989
• Est. Priority Date: 12/28/1984
• Status: Expired due to Fees

• Current Assignee: Johnson Matthey PLC
• Original Assignee: Johnson Matthey PLC
• Inventors: Smith, Peter R., Pratt, Allin S.
• Primary Examiner(s): Schofer, Joseph L.
• Assistant Examiner(s): Kulkosky, Peter F.
• Application Number:
  US06/814,413
• Time in Patent Office: 1,296 Days
• Field of Search: 523/116
• US Class Current: 424/409
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/802 Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

An antimicrobial composition which includes silver as the antimicrobial agent also includes a hydratable or hydrated oxide as a promoter to enhance the antimicrobial effect. Such compositions may be used to coat appliances such as catheters or may be incorporated in bone cements.

Claims

1. An antimicrobial composition for use in contact with materials which cause or are susceptible to bacterial infection by body fluids or tissue, said composition comprising metallic silver as the antimicrobial agent together with an oxide component selected from the group consisting of titanium and tantalum oxides present in an amount effective to provide release of silver ions into surrounding tissue or fluid.

2. An antimicrobial composition according to claim 1, in which the composition is dispersed in a polymeric material.

3. An antimicrobial composition according to claim 2, in which the composition constitutes from 1 to 75% by weight, based on the total of antimicrobial composition and cured polymer.

7. A medical or other appliance, characterized in that it is coated or impregnated with an antimicrobial composition according to claim 1.

8. A bone cement mixture comprising an acrylic powder, an acrylic monomer and a filler, characterized in that the filler includes an antimicrobial composition according to claim 1.

11. A composition according to claim 1 including 110% silver, the balance consisting essentially of titanium dioxide.

4. An antimicrobial composition according to in which the silver is deposited on particles of titanium dioxide.

5. An antimicrobial composition according to claim 4, which the mean particle size of the oxide is below 5 microns.

6. An antimicrobial composition according to 5, in which the surface area of the oxide particles is between 1 and 100 m² g^-1 inclusive.

9. In an antimicrobial composition comprising metallic silver as the antimicrobial agent and wherein the activity of said agent is undesirably affected in contact with body fluids, the improvement which comprises including in said composition titanium dioxide to enhance the activity of said agent.

10. In a method wherein metallic silver is used as an antimicrobial agent in the presence of fluids which tend to undesirably affect the antimicrobial activity of the silver, the improvement which comprises including titanium dioxide with the metallic silver to stabilize the activity of the silver against said fluids and to provide release of silver ions into the fluid to produce a sustained antimicrobial effect.