Composite macrostructure of ceramic and organic biomaterials

• US 4,849,285 A
• Filed: 06/01/1987
• Issued: 07/18/1989
• Est. Priority Date: 06/01/1987
• Status: Expired due to Fees

• Current Assignee: Bio Med Sciences Incorporated (Uluru Inc.)
• Original Assignee: Bio Med Sciences Incorporated (Uluru Inc.)
• Inventors: Dillon, Mark E.
• Primary Examiner(s): McCamish, Marion E.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/056,386
• Time in Patent Office: 778 Days
• Field of Search: 428/422, 428/330, 623/11, 623/13, 623/16, 623/16 D, 623/18, 623/23
• US Class Current: 428/330
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: C04B 14/36 Inorganic materials not provided for in groups C04B14/022 and C04B14/04 - C04B14/34
• CPC Class Codes: C04B 2111/00836 for medical or dental applications
• CPC Class Codes: C04B 22/062 of the alkali or alkaline-earth metals
• CPC Class Codes: C04B 24/2682 Halogen containing polymers, e.g. PVC
• CPC Class Codes: C04B 26/32 containing silicon
• CPC Class Codes: C04B 38/04 by dissolving-out added substances
• CPC Class Codes: C08J 2327/18 Homopolymers or copolymers of tetrafluoroethylene
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
• CPC Class Codes: C08K 3/32 Phosphorus-containing compounds
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: C08L 51/06 grafted on to homopolymers or copolymers of aliphatic hydrocarbons containing only one carbon-to-carbon double bond
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/258 Alkali metal or alkaline earth metal or compound thereof
• CPC Class Codes: Y10T 428/31544 Addition polymer is perhalogenated

Abstract

A composite self-supporting flexible agglomerated macrostructure is described which comprises (1) a matrix of unfibrillated polytetrafluoroethylene resin and addition curable silicone and (2) particulate material including hydroxyapatite and/or tricalcium phosphate uniformly distributed throughout said matrix, the macrostructure being uniformly permeated by a network of open pores formed in the process of manufacture by intimately blending particulate sodium chloride and subsequently leaching the sodium chloride particles.

Claims

1. A acomposite self-supporting flexible agglomerated macrostructure comprising (1) a matric consisting essentially of a blend of a major portion of unfibrillated polytetrafluoroethylene resin and a minor portion of an addition curable silicone composition, said blend having been heated sufficiently to sinter the polytetrafluoroethylene and to cure said silicone composition, and (2) a particulate material selected from the class consisting of hydroxyapatite and tricalcium phosphate, said particulate material having a maximum particle size of about 2,000 microns and being uniformly distributed throughout said matrix;

said macrostructure being uniformly permeated by a network of open pores having a maximum pore size of about 2,000 microns and an overall porosity of up to about 50 percent by volume; and

wherein said matrix comprises a major portion of said macrostructure and said particulate material comprises a minor portion of said macrostructure.

2. The composite macrostructure of claim 1, wherein the particulate material is hydroxyapatite.

3. The composite macrostructure of claim 1, wherein the particulate material is tricalcium phosphate.

4. The composite macrostructure of claim 1, wherein the particulate material is a mixture of hydroxyapatite and tricalcium phosphate.

5. The composite macrostructure of claim 1, wherein the particulate material has a particle size distribution between about 53 microns and 250 microns.

6. The composite macrostructure of claim 1, wherein the open pores range in size from about 53 microns to about 250 microns.