Bioelectrochemical modulation of biological functions using resonant/non-resonant fields synergistically

• US 4,850,959 A
• Filed: 08/02/1988
• Issued: 07/25/1989
• Est. Priority Date: 08/02/1988
• Status: Expired due to Fees

• Current Assignee: Bioresearch Incorporated
• Original Assignee: Bioresearch Incorporated
• Inventors: Findl, Eugene
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/227,296
• Time in Patent Office: 357 Days
• Field of Search: 600/1, 600/2, 600/13, 600/14, 600/15, 600/9
• US Class Current: 604/14
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/6831 Straps, bands or harnesses

Abstract

A method of controlling cellular influx and efflux of ionic calcium to modulate the functioning of biological entities comprising subjecting such entities to both resonant and non-resonant fields. Representative of the synergistic application of these two types of fields in their use in controlling blood glucose levels in living animals afflicted with hyperglycemia. This method comprising subjecting at least the liver and pancreas area of an animal having a blood glucose level of at least 180 mg/dL to a resonant electromagnetic field applied post-prandially until the animal'"'"'s blood glucose level is reduced to about 150 mg/dL then stopping application of said resonant frequency electromagnetic field and subjecting said animal to a non-resonant frequency electromagnetic field to further reduce the animal'"'"'s blood glucose level.

Claims

1. A method of controlling blood glucose levels in a living animal afflicted with hyperglycemia comprising subjecting at least the liver/pancreas area of said animal defined as having a fasting blood glucose level of at least 180 mg/dL to a resonant frequency electromagnetic field applied post-prandially on a daily basis until the animal'"'"'s fasting blood glucose level is reduced at least to about 150 mg/dL, then stopping application of said resonant frequency electromagnetic field and subjecting said animal to a non-resonant frequency electromagnetic field to further reduce the animal'"'"'s blood glucose level.

2. A method according to claim 1 wherein the resonant frequency electromagnetic field has a frequency of 15 Hz plus or minus 0.5 Hz and the non-resonant frequency electromagnetic field has a frequency of 23-28 Hz.

3. A method according to claim 1 wherein the resonant field is applied for about 0.5 to 2 hours.

4. A method according to claim 1 wherein the non-resonant field is applied for 0.5 to 1.5 hours.

5. A method according to claim 1 wherein both the resonant and non-resonant electromagnetic fields are substantially uniform magnetic fields of field strength ranging from 0.1 to 1,000 gauss.

6. A method of controlling cellular influx and efflux of ionic calcium which comprises applying to a secretory cell or cells during the functioning cycle of the cell or cells a resonant frequency field to cause said influx and a non-resonant frequency field to cause said efflux.

7. A method according to claim 6 wherein said cell or cells comprise pancreatic beta cells and wherein the resonant field causes an influx of ionic calcium into pancreatic beta cells to increase their insulin output, while conversely, the non-resonant field causes an efflux of ionic calcium to decrease their insulin output.

8. A method according to claim 6 wherein the resonant field is applied to liver hepatocyte cells and causes an influx of ionic calcium into said liver hepatocytes to activate the enzyme phosphorylase kinase, increasing the conversion of glycogen to glucose, while conversely, the non-resonant field when applied to said liver hepatocytes causes an efflux of ionic calcium from said hepatocytes, deactivating the enzyme phosphorylase kinase, to decrease the conversion of glycogen to glucose.

9. A method according to claim 6 wherein the step of applying the resonant and/or non-resonant fields comprises generating said fields electromagnetically by electric currents in field coils such as Helmholtz coils.

10. A method according to claim 6 wherein the step of applying resonant and non-resonant fields comprises applying vibratory or rotational motion to a permanent magnet.

11. A method according to claim 6 wherein the step of applying resonant and/or non-resonant fields comprises generating appropriately modulated radio frequency power sources.

12. A method according to claim 6 wherein the step of applying resonant and/or non-resonant fields comprises generating appropriately modulated ultrasonic power sources.

13. A method according to claim 7 further comprising measuring blood glucose levels over time, and wherein the resonant field is applied to said cells in vivo blood when glucose levels are elevated and the non-resonant field is applied when blood glucose levels are below normal to bring glucose levels to the normal range.

14. A method according to claim 7 wherein said cells further comprise pancreatic alpha cells and wherein the resonant field causes an influx of ionic calcium into said pancreatic alpha cells to decrease glucagon output, while conversely, the non-resonant field causes an efflux of ionic calcium from said pancreatic alpha cells to increase glucagon output.

15. A method according to claim 14 further comprising measuring blood glucose levels over time, and wherein the resonant field is applied to said cells in vivo when blood glucose levels are elevated and the non-resonant field is applied when blood glucose levels are below normal to bring glucose levels to the normal range.

16. A method according to claim 8 wherein the resonant field is applied when glucose levels are low and the non-resonant field is applied when glucose levels are high to bring glucose levels to normal range.

17. A method of controlling blood glucose levels in a living animal afflicted with hypoglycemia, comprising subjecting at least the liver/pancreas area of an animal defined as having a fasting blood sugar level less than 80 mg/dL to a non-resonant electromagnetic field applied pre-prandially on a daily basis until the animal'"'"'s blood glucose level is increased to between 80 and 120 mg/dL.