Anti-dementia agent

• US 4,851,414 A
• Filed: 08/08/1988
• Issued: 07/25/1989
• Est. Priority Date: 08/10/1987
• Status: Expired due to Fees

• Current Assignee: Kyowa Hakko Kogyo Company Limited 6-1 Ohtemachi Itchome Chiyoda-Ku Tokyo Japan
• Original Assignee: Kyowa Hakko Kogyo Company Limited (Kirin Holdings Company Limited)
• Inventors: Shiozaki, Shizuo, Shuto, Katsuichi, Oiji, Yoshimasa
• Primary Examiner(s): FRIEDMAN, STANLEY
• Application Number:
  US07/229,824
• Time in Patent Office: 351 Days
• Field of Search: 514/277
• US Class Current: 514/277
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Disclosed are anti-dementia agents comprising an antiamnestically effective amount of a benzylpyridine derivative of the formula ##STR1## wherein R is an alkyl group. The invention also pertains to the treatment of dementia by administration of such anti-dementia agent.

Claims

1. A method of treating dementia which comprises administering to a patient suffering from dementia an antiamnestically effective amount of a benzylpyridine derivative of the formula:

##STR4## wherein R represents an alkyl group or a pharmaceutically acceptable acid addition salt thereof.

2. A method of treating dementia according to claim 1 wherein said pharmaceutically acceptable acid addition saltis are selected from the group consisting of hydrochloride, hydrobromide, sulfate, phosphate, acetate, oxalate, succinate, malate, tartrate, citrate and fumarate.

3. A method of treating dementia according to claim 1 wherein said antiamnestically effective amount comprises a daily dosage of from 5 to 500 mg.

4. A method of treating dementia according to claim 1 wherein said antiamnestically effective amount comprises a daily dosage of from 20 to 100 mg.